Targeted Protein Degradation:

Daria       Kotlarek; Agata       Pawlik; Maria       Sagan; Marta       Sowała; Alina       Zawiślak-Architek; Michał   J.    Walczak
Abstract

Targeted Protein Degradation (TPD) is an emerging new modality of drug discovery that offers unprecedented therapeutic benefits over traditional protein inhibition. Most importantly, TPD unlocks the untapped pool of the proteome that to date has been considered undruggable. Captor Therapeutics (Captor) is the fourth global, and first European, company that develops small molecule drug candidates based on the principles of targeted protein degradation. Captor is located in Basel, Switzerland and Wroclaw, Poland and exploits the best opportunities of the two sites – experience and non-dilutive European grants, and talent pool, respectively. Through over $38 M of funding, Captor has been active in three areas of TPD: molecular glues, bi-specific degraders and direct degraders, ObteronsTM.
Keywords: Targeted protein degradation, PROTAC, degraders, proteasome, cancer, oncology.
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DOI https://dx.doi.org/10.2174/2213809907666200130111436	Print ISSN 2213-8099
Publisher Name Bentham Science Publisher	Online ISSN 2213-8102
Technology Transfer and Entrepreneurship (Discontinued)

Targeted Protein Degradation: "The Gold Rush is On!"

Abstract
