Renin-Angiotensin-Aldosterone System and Migraine: A Systematic Review of Human Studies

Author(s): Karina Lúcia Moreira Sassi, Laís Bhering Martins, Aline Silva de Miranda, Antonio Lucio Teixeira*

Journal Name: Protein & Peptide Letters

Volume 27 , Issue 6 , 2020

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Graphical Abstract:


Migraine is a common neurologic condition marked by recurrent episodes of headache. Its pathophysiology is highly complex involving neuronal, inflammatory and vascular mechanisms. The Renin-Angiotensin System (RAS) can modulate all these mechanism, being a potential pharmacological target for migraine treatment. We carried out a systematic review of the studies evaluating the involvement of RAS in patients with migraine. There is evidence from genetic studies exploring the relation between migraine and RAS-related genes and from clinical trials evaluating the efficacy of Angiotensin II Type 1 (AT1) receptor antagonists and angiotensin converting enzyme inhibitors in migraine prophylaxis. RAS seems to play a role in the pathophysiology of migraine, but more direct evidence is still missing.

Keywords: Renin, angiotensin, aldosterone, migraine, headache, genetics.

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Article Details

Year: 2020
Published on: 09 June, 2020
Page: [512 - 519]
Pages: 8
DOI: 10.2174/0929866527666200129160136
Price: $65

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