Background: Resveratrol is a wonder therapy for the treatment of several skin
disorders, including psoriasis, but its skin permeation limits its applications.
Objective: The present work dealt with optimizing and formulating resveratrol loaded vitamin
E based nanoemulsion and carbomer based nanoemulgel intended for topical application
in the treatment of plaque psoriasis.
The major objective of this study was to achieve the quality target product profile with respect
to enhanced skin permeation and superior skin deposition of the formulated
nanoemulgel to achieve the superlative therapeutic advantages.
Methods: Formulation by design (FbD) approach was employed to optimize varied critical
material attributes such as the concentration of oil and Smix to achieve the desired quality
characteristics. Carbomer based nanoemulgel was formulated and evaluated.
Results: Optimized formulation was having globule size (168.3 ± 4.98 nm), percentage
cumulative permeation (4.81 ± 0.65%), permeation flux (7.62 ± 0.39 μg hr-1cm-2), and skin
deposition (668.65 ± 11.98 μg cm-2). Nanoemulgel was found to have optimum physical
properties in terms of viscosity, spreadability, pH and physical stability. The extent of skin
deposition was approximately 6.682 times higher while the permeation enhancement ratio
was around 2.872 as compared to conventional formulation indicating its higher skin targeting
abilities, which was further ratified by Confocal Laser Scanning Microscopy results.
Conclusion: Nanoemulgel formulated by the current FbD approach has enhanced skin
permeation and skin deposition properties as compared to conventional carbomer gel.
Thus, it could augment the therapeutic benefits of encapsulated bioactive in the treatment
of several skin disorders like psoriasis.