Circular RNA and Diabetes: Epigenetic Regulator with Diagnostic Role

Author(s): Kazem Abbaszadeh-Goudarzi, Shabnam Radbakhsh, Mohammad Hossein Pourhanifeh, Hashem Khanbabaei, Amirhosein Davoodvandi, Hadis Fathizadeh, Amirhossein Sahebkar, Mohammad Karim Shahrzad*, Hamed Mirzaei*

Journal Name: Current Molecular Medicine

Volume 20 , Issue 7 , 2020


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Abstract:

Circular RNAs, a group of endogenous non-coding RNAs, are characterized by covalently closed cyclic structures with no poly-adenylated tails. It has been recently recommended that cirRNAs have an essential role in regulating genes expression by functioning as a translational regulator, RNA binding protein sponge and microRNA sponge. Due to their close relation to the progression of various diseases such as diabetes, circRNAs have become a research hotspot. A number of circRNAs (i.e., circRNA_0054633, circHIPK3, circANKRD36, and circRNA11783-2) have been shown to be associated with initiation and progression of diabetes. Based on reports, in a tissue, some circRNAs are expressed in a developmental stage-specific manner. In this study, we reviewed research on circular RNAs involved in the pathogenesis and diagnosis of diabetes and their prognostic roles.

Keywords: Circular RNA, diabetes, biomarker, circRNA_0054633, circHIPK3, circANKRD36.

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Article Details

VOLUME: 20
ISSUE: 7
Year: 2020
Page: [516 - 526]
Pages: 11
DOI: 10.2174/1566524020666200129142106

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