Title:Design and Fabrication of a Magnetite-based Polymer-supported Hybrid Nanocomposite: A Promising Heterogeneous Catalytic System Utilized in Known Palladium-assisted Coupling Reactions
VOLUME: 23 ISSUE: 2
Author(s):Ali Maleki*, Reza Taheri-Ledari and Reza Ghalavand
Affiliation:Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114
Keywords:Carbon-carbon coupling, magnetic nanocatalyst, palladium-catalyzed, poly(4-vinylpyridine), Suzuki reaction,
catalytic system.
Abstract:
Objective: Herein, a novel heterogeneous catalytic system constructed of iron oxide and
palladium nanoparticles is presented. Firstly, a convenient synthetic pathway for the preparation of this
catalytic system is introduced, then the application of the fabricated nanocomposite in the Pd-catalyzed
C─C coupling reactions is monitored. High reaction yields (98%) have been obtained in short reaction
time, by using this catalytic system.
Materials and Methods: Fe3O4/P4VP-Pd catalytic system was fabricated via an in situ method by 4-
vinylpyridine (4-VP). In this regard, all the essential structural analyses such as FT-IR, EDX, VSM, and
TGA have been performed on the Fe3O4/P4VP-Pd catalytic system to investigate its properties. The
spherical morphology of the NPs and their uniform size have also been studied by the SEM method.
Further, the reaction progress was controlled by thin-layer chromatography. Finally, NMR analysis was
used to identify the synthesized biphenyl pharmaceutical derivatives.
Results: High efficiency of this catalytic system has been precisely investigated and the optimal conditions
were determined. The catalytic process is carried out in 20 min, under mild conditions (room temperature).
Then, the purification process is easily performed via magnetic separation of the catalyst NPs. After
completion of the synthesis reaction, the NPs were collected, washed, and reused several times.
Conclusion: Among recently reported heterogeneous catalytic systems, Fe3O4/P4VP-Pd is recommended
due to its high catalytic performance, convenience of the preparation process, excellent biocompatibility,
economic benefits, and well reusability. Overall, in order to save time in the complex synthetic processes
and also prevent using so many chemical reagents and solvents for the purification process, the presented
catalytic system could be suitable for scaling up and applying for the industrial applications.
