Recent Development of 1,2,4-triazole-containing Compounds as Anticancer Agents

Author(s): Xiaoyue Wen, Yongqin Zhou*, Junhao Zeng, Xinyue Liu

Journal Name: Current Topics in Medicinal Chemistry

Volume 20 , Issue 16 , 2020

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Abstract:

1,2,4-Triazole derivatives possess promising in vitro and in vivo anticancer activity, and many anticancer agents such as fluconazole, tebuconazole, triadimefon, and ribavirin bear a 1,2,4-triazole moiety, revealing their potential in the development of novel anticancer agents. This review emphasizes the recent advances in 1,2,4-triazole-containing compounds with anticancer potential, and the structureactivity relationships as well as mechanisms of action are also discussed.

Keywords: 1, 2, 4-triazole, Anticancer, Structure-activity relationship, Fluconazole, Tebuconazole, Triadimefon, Ribavirin.

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Article Details

VOLUME: 20
ISSUE: 16
Year: 2020
Page: [1441 - 1460]
Pages: 20
DOI: 10.2174/1568026620666200128143230
Price: $65

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