Alzheimer’s disease is one of the most progressive forms of dementia, ultimately leading
to death in aged populations. The major hallmarks of Alzheimer’s disease include deposition of
extracellular amyloid senile plaques and intracellular neurofibrillary tangles in brain neuronal cells.
Although there are classical therapeutic options available for the treatment of the diseases, however,
they provide only a symptomatic relief and do not modify the molecular pathophysiological course
of the disease. Recent research advances in Alzheimer’s disease have highlighted the potential role
of anti-amyloid, anti-tau, and anti-inflammatory therapies. However, these therapies are still in different
phases of pre-clinical/clinical development. In addition, drug repositioning/repurposing is
another interesting and promising approach to explore rationalized options for the treatment of Alzheimer’s
This review discusses the different aspects of the pathophysiological mechanism involved in the
progression of Alzheimer’s disease along with the limitations of current therapies. Furthermore, this
review also highlights emerging investigational drugs along with recent drug repurposing approaches
for Alzheimer’s disease.