Title:OMEGA-3 Interventions in Alcohol Dependence and Related Outcomes: A Systematic Review and Propositions
VOLUME: 18 ISSUE: 5
Author(s):José Carlos F. Galduróz*, Andréia Gomes Bezerra, Gabriel Natan Pires, Renata Pauluci and Ana Regina Noto
Affiliation:Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Sao Paulo, Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Sao Paulo, Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Sao Paulo, Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Sao Paulo, Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Sao Paulo
Keywords:PUFAs, omega-3, ethanol, relapse, treatment, craving.
Abstract:
Background: Pharmacological treatment for alcohol dependence has only three approved
drugs: disulfiram, naltrexone and acamprosate. The effects of these drugs are, however, limited,
presenting several side effects and a modestly higher efficacy compared to placebo. The administration
of omega-3 might bring new perspectives to relapse prevention.
Methods: This systematic review aimed to analyze the available literature, compiling the studies
that used omega-3 to prevent relapse in alcohol dependents.
Results: The databases used were PubMed and Web of Science. We identified 2,231 studies and
only five articles addressed the administration of omega-3 and alcoholism. Preclinical studies
evaluating the effects of PUFAs related to chronic alcohol administration showed improvements in
behavioral, cellular and molecular levels. The clinical trial yielded inconclusive results.
Conclusion: Despite the reduced number of studies, omega-3 interventions seem to be promising
for controlling issues related to alcohol dependence.