Does Pharmacodynamics of Drugs Change After Presenting them as Nanoparticles Like their Pharmacokinetics?

Author(s): Razieh Mohammad Jafari, Moein Ala, Navid Goodarzi, Ahmad Reza Dehpour*

Journal Name: Current Drug Targets

Volume 21 , Issue 8 , 2020


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Graphical Abstract:


Abstract:

Nowadays, the breakthrough in different medical branches makes it feasible to designate new methods of drug delivery to achieve the most cost-effective and the least unpleasant consequenceimposing solutions to overcome a wide range of diseases.

Nanoparticle (NP) drugs entered the therapeutic system, especially in cancer chemotherapy. These drugs are quite well-known for two traits of being long-acting and less toxic. For a long time, it has been investigated how NPs will change the kinetics of drugs. However, there are a few studies that inclined their attention to how NPs affect the dynamics of drugs. In this review, the latter point will mainly be discussed in an example-based manner. Besides, other particular features of NPs will be briefly noted.

NPs are capable of affecting the biologic system as much as a drug. Moreover, NPs could arise a wide variety of effects by triggering their own receptors. NPs are able to change a receptor function and manipulate its downstream signaling cascade.

Keywords: Nanoparticles, pharmacodynamics, post receptor effects, drug-receptor interaction, drug delivery, kinetics of drugs.

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VOLUME: 21
ISSUE: 8
Year: 2020
Published on: 27 January, 2020
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DOI: 10.2174/1389450121666200128113547
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