Antibacterial Agents Targeting the Bacterial Cell Wall

Author(s): Li Shan, Qin Wenling*, Panunzio Mauro, Biondi Stefano*

Journal Name: Current Medicinal Chemistry

Volume 27 , Issue 17 , 2020


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Abstract:

The introduction of antibiotics to treat bacterial infections either by killing or blocking their growth has been accompanied by the studies of mechanism that allows the drugs to kill the bacteria or to stop their proliferation. In such a scenario, the emergence of antibacterial agents active on the bacterial cell wall has been of fundamental importance in the fight against bacterial agents responsible for severe diseases. As a matter of fact, the cell wall, which plays many roles during the lifecycle, is an essential constituent of most bacteria. This overview focuses on the intracellular steps of peptidoglycan biosynthesis and the research of new antibacterial agents based on the enzymes involved in these early steps of the formation of cell membrane components.

Keywords: Antibiotics, bacterial cell wall, peptidoglycan, murein enzymes, review, bacterial infections.

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VOLUME: 27
ISSUE: 17
Year: 2020
Published on: 04 June, 2020
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DOI: 10.2174/0929867327666200128103653
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