A Review of Conifers in Iran: Chemistry, Biology and their Importance in Traditional and Modern Medicine

Author(s): Maryam Akaberi, Zahra Boghrati, Mohammad S. Amiri, Mohammad H. Khayyat*, Seyed A. Emami*.

Journal Name: Current Pharmaceutical Design

Volume 26 , Issue 14 , 2020

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Abstract:

Cupressus sempervirens, Platycladus orientalis, Juniperus communis, J. excelsa, J. foetidissima, J. polycarpos var. turcomanica, J. sabina, and Taxus baccata are conifers in Iran. These plants have a long reputation in different systems of traditional medicines for a variety of diseases. This review aims to provide comprehensive and up-to-date information about the ethnopharmacological uses, chemical constituents, and pharmacology of these conifers. Furthermore this study comprises a bibliographical survey of major Islamic Traditional Medicine (ITM) books regarding different medical aspects of these species. A literature search was conducted on the applications of these conifers both in traditional and modern medicines by referencing traditional textbooks and scientific databases. Ethnobotanical literature review indicates that various parts of the plants including cones, berries, leaves, bark, wood, and resin have been used for a broad spectrum of applications. In Iran, C. sempervirens, J. sabina, J. communis, and T. baccata have been used traditionally for the treatment of urinary, digestive, nervous, respiratory, and integumentary systems-related problems. The phytochemical constituents of these plants can be divided into two main categories: volatile and non-volatile components, all dominated by terpenes. Considering the pharmacological and clinical evidence, while some of the traditional applications of these plants are supported by modern medicine, implying the value of the traditional and folklore knowledge for finding new lead compounds in drug discovery, some have remained unexamined showing the need for much more studies in this regard.

Keywords: Conifers, Cupressus, Juniperus, Taxus, Platycladus, Cupressaceae, Taxaceae, traditional medicine, pharmacology.

[1]
Ghahremaninejad F, Ataei N, Nejad Falatoury A. Comparison of angiosperm flora of Afghanistan and Iran in accordance with APG IV system. Nova Biologica Reperta 2017; 4: 74-99.
[http://dx.doi.org/10.21859/acadpub.nbr.4.1.74]
[2]
Davis SD, Heywood VH, Hamilton AC. Europe, Africa, South West Asia and the Middle East Centers of Plant Diversity: A Guide and Strategy for their Conservation 1994.
[3]
Brofas G, Karetsos G, Dimopoulos P, Tsagari C. The natural environment of Cupressus sempervirens in Greece as a basis for its use in the Mediterranean region. Land Degrad Dev 2006; 17: 645-59.
[http://dx.doi.org/10.1002/ldr.750]
[4]
Seca AML, Silva AMS. The chemical composition of the Juniperus genus (1970-2004). Recent Progress in Medicinal Plants 2006; pp. 401-522.
[5]
Adams RP. Junipers of the World: The Genus. Juniperus. 4th ed. 2011.
[6]
van Rozendaal ELM, Kurstjens SJL, van Beek TA, van den Berg RG. Chemotaxonomy of Taxus. Phytochemistry 1999; 52: 427-33.
[http://dx.doi.org/10.1016/S0031-9422(99)00229-0]
[7]
Wilson CR, Sauer J, Hooser SB. Taxines: A review of the mechanism and toxicity of yew (Taxus spp.) alkaloids. Toxicon 2001; 39: 175-85.
[http://dx.doi.org/10.1016/S0041-0101(00)00146-X]
[8]
Mozaffarian V. Identification of medicinal and aromatic plants of Iran 2013; 1444.
[9]
Jalali H, Nejad AM, Ebadi AG, Laey G. Ethnobotany and folk pharmaceutical properties of major trees or shrubs in northeast of Iran. Asian J Chem 2009; 21: 5632-8.
[10]
Pirani A, Moazzeni H, Mirinejad S, Naghibi F, Mosaddegh M. Ethnobotany of Juniperus excelsa M. Bieb. (Cupressaceae) in Iran. Ethnobot Res Appl 2011; 9: 335-41.
[http://dx.doi.org/10.17348/era.9.0.335-341]
[11]
Ghorbani A, Aghjeh Qeshlagh M, Karamati Jabehdar S. Folk herbal veterinary medicines of Tehran Watershed (Iran). J Herb Drug 2015; 6: 31-9.
[12]
Atashgahi Z, Ejtehadi H, Mesdaghi M, Ghassemzadeh F. Plant diversity of the Heydari Wildlife Refuge in northeastern Iran, with a checklist of vascular plants. Phytotaxa 2018; 340: 101-27.
[http://dx.doi.org/10.11646/phytotaxa.340.2.1]
[13]
Emami SA, Asgary S, Naderi GA, et al. Investigation of antioxidant and anti-glycation properties of essential oils from fruits and branchlets of Juniperus oblonga. Braz J Pharmacog 2012; 22: 985-93.
[http://dx.doi.org/10.1590/S0102-695X2012005000045]
[14]
Baharvand-Ahmadi B, Bahmani M, Tajeddini P, Rafieian-Kopaei M, Naghdi N. An ethnobotanical study of medicinal plants administered for the treatment of hypertension. J Renal Inj Prev 2016; 5: 123-8.
[http://dx.doi.org/10.15171/jrip.2016.26]
[15]
Al-Antâki D. Tadkirat Olo al-Albâb wa al-Jâmʿe le al-ʿAjb al-ʿUjâb. The Reminder to Wise People and the Miraculous Collector 2001.
[16]
Razi MZ. Al-Hawi fi’l-Ṭibb (Continens) Hyderabad:. 1967-68.
[17]
Ghasani AM. Hadiqat al-Azhar fi Mahiyyat al-ushb wa al-uqqar 1985.
[18]
Ibn Beytar AA. Al-Jâmʿe le-Mofradaât al-Adwiah wa al-Aġhdiyah (Comprehensive Book in Simple Drugs and Foods) Beirut: Dar- Al-Kotob Al-ʿIlmiyah. 1992.
[19]
Ibn Nafiss Qarshi AI. Al-Shamil fi al-Sanʿa't al-Tibbiah (The Comprehensive Book on the Art of Medicine) Abu Zabi: al Majmʿa al-Taqafi. 2000.
[20]
Bedevian AK. Illustrated polyglottic dictionary of plant names in Latin, Arabic, Armenian, English, French, German, Italian, and Turkish languages 2006.
[21]
Husseini Tonekaboni MM. Tohfah al-Momenin (Rarity of the Faithful) 2008.
[22]
Aqili Alawi Khorasani Shirazi MH. Makhzan al-Adwiyah. (Drug Treasure) 2014.
[23]
Ibn Sina HA. Al-Qanun fi'l-Tibb (The Canon of Medicine) Tehran: Almaʿee. 2015.
[24]
Laid B, Rebbas K, Mouloud G, Rabah B, Faiçal B, Bouzerzour H. Ethnobotanical study of medinal plants in Djebel Messaad region (M’sila, Algeria). Glob J Res Med Plants Indig Med 2014; 3: 445-59.
[25]
Parada M, Carrio E, Bonet MA, Valles J. Ethnobotany of the Alt Emporda region (Catalonia, Iberian Peninsula): plants used in human traditional medicine. J Ethnopharmacol 2009; 124: 609-18.
[http://dx.doi.org/10.1016/j.jep.2009.04.050]
[26]
Guarrera PM, Forti G, Marignoli S. Ethnobotanical and ethnomedicinal uses of plants in the district of Acquapendente (Latium, Central Italy). J Ethnopharmacol 2005; 96: 429-44.
[http://dx.doi.org/10.1016/j.jep.2004.09.014]
[27]
Estrada-Castillón E, Villarreal-Quintanilla JA, Salinas-R M, et al. Ethnobotanical survey of useful species in Bustamante, Nuevo León, Mexico. Hum Ecol 2018; 46: 117-32.
[http://dx.doi.org/10.1007/s10745-017-9962-x]
[28]
El-Darier SM, El-Mogaspi FM. Ethnobotany and relative importance of some endemic plant species at El-Jabal El-Akhdar Region (Libya). World J Agric Sci 2008; 5: 353-60.
[29]
Akdime H, Boukhira S, El Mansouri L, El Youbi AH, Bousta D. Ethnobotanical study and traditional knowledge of medicinal plants in Ain Leuh Region (middle-atlas of Morocco). Am J Adv Drug Deliv 2015; 3: 248-63.
[30]
Ullah Z, Rashid A, Shah M, Ali M, Gul H, Khan A. Ethnobotanical studies of medicinal plants of Malakand district. Fuuast J Biol 2018; 8: 161-7.
[31]
Yesilada E, Sezik E, Honda G, Takaishi Y, Takeda Y, Tanaka T. Traditional medicine in Turkey IX: folk medicine in north-west Anatolia. J Ethnopharmacol 1999; 64: 195-210.
[http://dx.doi.org/10.1016/S0378-8741(98)00133-0]
[32]
Gurdal B, Kultur S. An ethnobotanical study of medicinal plants in Marmaris (Mugla, Turkey). J Ethnopharmacol 2013; 146: 113-26.
[http://dx.doi.org/10.1016/j.jep.2012.12.012]
[33]
Gençay A, Ayşegül C. Ethnobotanical purposes of plants sold by herbalists and folk bazaars in the center of Cappadocica (Nevşehir, Turkey). Indian J Tradit Knowl 2016; 15: 103-8.
[34]
Baana K, Angwech H, Malinga GM. Ethnobotanical survey of plants used as repellents against housefly, Musca domestica L. (Diptera: Muscidae) in Budondo Subcounty, Jinja District, Uganda. J Ethnobiol Ethnomed 2018; 14: 35-5.
[http://dx.doi.org/10.1186/s13002-018-0235-6]
[35]
Pieroni A, Elena Giusti M, Münz H, Lenzarini C, Turković G, Turković A. Ethnobotanical knowledge of the Istro-Romanians of Žejane in Croatia. Fitoterapia 2003; 74: 710-9.
[http://dx.doi.org/10.1016/j.fitote.2003.06.002]
[36]
Jaric S, Popovic Z, Macukanovic-Jocic M, et al. An ethnobotanical study on the usage of wild medicinal herbs from Kopaonik Mountain (Central Serbia). J Ethnopharmacol 2007; 111: 160-75.
[http://dx.doi.org/10.1016/j.jep.2006.11.007]
[37]
Bonet MA, Valles J. Ethnobotany of Montseny biosphere reserve (Catalonia, Iberian Peninsula): plants used in veterinary medicine. J Ethnopharmacol 2007; 110: 130-47.
[http://dx.doi.org/10.1016/j.jep.2006.09.016]
[38]
Carpenter CD, O’Neill T, Picot N, et al. Anti-mycobacterial natural products from the Canadian medicinal plant Juniperus communis. J Ethnopharmacol 2012; 143: 695-700.
[http://dx.doi.org/10.1016/j.jep.2012.07.035]
[39]
Hussain M, Shah G, Khan M. Traditional medicinal and economic uses of gymnosperms of Kaghan Valley, Pakistan. Ethnobot Leaflets 2006; 13: 1509-21.
[40]
Tuzlac E, Erol MK. Turkish folk medicinal plants. Part II: Eğirdir (Isparta). Fitoterapia 1999; 70: 593-610.
[http://dx.doi.org/10.1016/S0367-326X(99)00074-X]
[41]
Özgen U, Kaya Y, Houghton P. Folk medicines in the villages of IlIca District (Erzurum), Turkey. Turk J Biol 2012; 36: 93-106.
[42]
Fujita T, Sezik E, Tabata M, et al. Traditional medicine in Turkey VII. Folk medicine in middle and west Black Sea regions. Econ Bot 1995; 49: 406.
[http://dx.doi.org/10.1007/BF02863092]
[43]
Singh H, Husain T, Agnihotri P, Pande PC, Khatoon S. An ethnobotanical study of medicinal plants used in sacred groves of Kumaon Himalaya, Uttarakhand, India. J Ethnopharmacol 2014; 154: 98-108.
[http://dx.doi.org/10.1016/j.jep.2014.03.026]
[44]
Kumari S, Batish DR, Singh HP, Negi K, Kohli RK. An ethnobotanical survey of medicinal plants used by Gujjar community of Trikuta hills in Jammu and Kashmir, India. J Med Plants Res 2013; 7: 2111-21.
[http://dx.doi.org/10.5897/JMPR12.528]
[45]
Bharati KA, Sharma BL. Some ethnoveterinary plant records for Sikkim Himalaya. Indian J Tradit Knowl 2010; 9: 344-6.
[46]
Avinash K. Ethnomedicines of Tharu tribes of Dudhwa national park. Ethnobotany Res App 2014; 12(1)
[47]
Mustafa B, Hajdari A, Pajazita Q, Syla B, Quave CL, Pieroni A. An ethnobotanical survey of the Gollak region, Kosovo. Genet Resour Crop Evol 2012; 59: 739-54.
[http://dx.doi.org/10.1007/s10722-011-9715-4]
[48]
Simkova K, Polesny Z. Ethnobotanical review of wild edible plants used in the Czech Republic. J Appl Bot Food Qual 2015; 88: 49-67.
[49]
Akerreta S, Calvo MI, Cavero RY. Ethnoveterinary knowledge in Navarra (Iberian Peninsula). J Ethnopharmacol 2010; 130: 369-78.
[http://dx.doi.org/10.1016/j.jep.2010.05.023]
[50]
Pranskuniene Z. Urban ethnobotany study in Samogitia region, Lithuania. J Med Plant Res 2010; 4: 064-71.
[51]
Menkovic N, Savikin K, Tasic S, et al. Ethnobotanical study on traditional uses of wild medicinal plants in Prokletije Mountains (Montenegro). J Ethnopharmacol 2011; 133: 97-107.
[http://dx.doi.org/10.1016/j.jep.2010.09.008]
[52]
Rexhepi B, Mustafa B, Hajdari A, Rushidi-Rexhepi J, Quave CL, Pieroni A. Traditional medicinal plant knowledge among Albanians, Macedonians and Gorani in the Sharr Mountains (Republic of Macedonia). Genet Resour Crop Evol 2013; 60: 2055-80.
[http://dx.doi.org/10.1007/s10722-013-9974-3]
[53]
Savikin K, Zdunic G, Menkovic N, et al. Ethnobotanical study on traditional use of medicinal plants in South-Western Serbia, Zlatibor district. J Ethnopharmacol 2013; 146: 803-10.
[http://dx.doi.org/10.1016/j.jep.2013.02.006]
[54]
Hassanzadeh-Khayyat M, Akaberi M, Moalemzadeh Haghighi H, Sahebkar A, Emami SA. Distribution and variability of n-alkanes in waxes of conifers. J For Res 2018; 30: 429-33.
[http://dx.doi.org/10.1007/s11676-018-0639-0]
[55]
Parvin Salehi S, Mirza M, Calagari M. Composition of the essential oils of junipers (Juniperus foetidissima and J. oblonga) from Arasbaran protected area. J Essent Oil-Bear Pl 2016; 19: 1261-6.
[http://dx.doi.org/10.1080/0972060X.2014.1001193]
[56]
Hammoda HM, Harraz FM, Farag MA, El-Aswad AF, El-Hawiet A, Eid AM. Volatiles profiling and bioactivities of Cupressus spp. leaf and cone essential oils as analyzed via chemometrics tools. J Essent Oil Res 2018; 31: 53-62.
[http://dx.doi.org/10.1080/10412905.2018.1496857]
[57]
Chanegriha N, Baâliouamer A, Meklati BY, Favre-Bonvin J, Alamercery S. Chemical composition of Algerian cypress essential oil. J Essent Oil Res 1993; 5: 671-4.
[http://dx.doi.org/10.1080/10412905.1993.9698304]
[58]
Hajdari A, Mustafa B, Nebija D, Miftari E, Quave CL, Novak J. Chemical composition of Juniperus communis L. cone essential oil and its variability among wild populations in Kosovo. Chem Biodivers 2015; 12: 1706-17.
[http://dx.doi.org/10.1002/cbdv.201400439]
[59]
Rezvani S. Analysis of essential oil of Juniperus communis and terpenoids dried fruits from Golestan of Iran. Asian J Chem 2010; 22: 1652-4.
[60]
Sanei-Dehkordi A, Gholami S, Abai MR, Sedaghat MM. Essential oil composition and larvicidal evaluation of Platycladus orientalis against two mosquito vectors, Anopheles stephensi and Culex pipiens. J Arthropod Borne Dis 2018; 12: 101-7.
[http://dx.doi.org/10.18502/jad.v12i2.35]
[61]
Afsharypuor S, Nayebzadeh B. Essential oil constituents of young stem, leaf and fruit of Platycladus orientalis (L.) Franco grown in Isfahan (Iran). J Essent Oil Res 2009; 21: 525-8.
[http://dx.doi.org/10.1080/10412905.2009.9700235]
[62]
Loizzo MR, Saab AM, Tundis R, et al. Phytochemical analysis and in vitro antiviral activities of the essential oils of seven Lebanon species. Chem Biodivers 2008; 5: 461-70. a
[http://dx.doi.org/10.1002/cbdv.200890045]
[63]
Hafi MA, Cazier F, Aboukais A, Jocelyne B, Beyrouthy ME. Chemical composition of the essential oils from berries, leaves, and twigs of Juniperus excelsa M. Bieb. growing wild in Lebanon. J Essent Oil-Bear Pl 2015; 18: 844-51.
[http://dx.doi.org/10.1080/0972060X.2014.901626]
[64]
Falasca A, Caprari C, De Felice V, et al. GC-MS analysis of the essential oils of Juniperus communis L. berries growing wild in the Molise region: Seasonal variability and in vitro antifungal activity. Biochem Syst Ecol 2016; 69: 166-75.
[http://dx.doi.org/10.1016/j.bse.2016.07.026]
[65]
Radulović N, Blagojević P, Palić R, Zlatković B. Chemical composition of the essential oil hydrodistilled from Serbian Taxus baccata L. J Essent Oil Res 2010; 22: 458-61.
[http://dx.doi.org/10.1080/10412905.2010.9700371]
[66]
Maurya AK, Devi R, Kumar A, et al. Chemical composition, cytotoxic and antibacterial activities of essential oils of cultivated clones of Juniperus communis and wild Juniperus species. Chem Biodivers 2018; 15 e1800183
[http://dx.doi.org/10.1002/cbdv.201800183]
[67]
Asili J, Emami SA, Rahimizadeh M, Fazly-Bazzaz BS, Hassanzadeh MK. Chemical and antimicrobial studies of Juniperus sabina L. and Juniperus foetidissima willd. Essential oils. J Essent Oil-Bear Pl 2010; 13: 25-36.
[http://dx.doi.org/10.1080/0972060X.2010.10643787]
[68]
Stefanovic M, Ristic M, Popovic Z, et al. Chemical composition and interpopulation variability of essential oils of Taxus baccata L. from Serbia. Chem Biodivers 2016; 13: 943-53.
[http://dx.doi.org/10.1002/cbdv.201500326]
[69]
Sampietro DA, Gomez ADLA, Jimenez CM, et al. Chemical composition and antifungal activity of essential oils from medicinal plants of Kazakhstan. Nat Prod Res 2017; 31: 1464-7.
[http://dx.doi.org/10.1080/14786419.2016.1258560]
[70]
Ulukanli Z, Karabörklü S, Ates B, Erdogan S, Cenet M, Karaaslan MG. Chemical composition of the essential oil from Cupressus sempervirens L. horizontalis resin in conjunction with its biological assessment. J Essent Oil-Bear Pl 2014; 17: 277-87.
[http://dx.doi.org/10.1080/0972060X.2014.895161]
[71]
Fahed L, Khoury M, Stien D, Ouaini N, Eparvier V, El Beyrouthy M. Essential oils composition and antimicrobial activity of six conifers harvested in Lebanon. Chem Biodivers 2017; 14
[http://dx.doi.org/10.1002/cbdv.201600235]
[72]
Ben Nouri A, Dhifi W, Bellili S, et al. Chemical composition, antioxidant potential, and antibacterial activity of essential oil cones of Tunisian Cupressus sempervirens. J Chem 2015; 2015(Article ID 538929): 8.
[73]
Sela F, Karapandzova M, Stefkov G, Cvetkovikj I, Kulevanova S. Chemical composition and antimicrobial activity of essential oils of Juniperus excelsa Bieb. (Cupressaceae) grown in R. Macedonia. Pharmacol Res 2015; 7: 74-80.
[74]
Atas AD, Goze I, Alim A, et al. Chemical composition, antioxidant, antimicrobial and antispasmodic activities of the essential oil of Juniperus excelsa subsp. excelsa. J Essent Oil-Bear Pl 2012; 15: 476-83.
[http://dx.doi.org/10.1080/0972060X.2012.10644075]
[75]
Dahmane D, Dob T, Chelghoum C. Essential oil composition and enantiomeric distribution of some monoterpenoid components of Juniperus communis L. from Algeria. J Essent Oil Res 2016; 28: 348-56.
[http://dx.doi.org/10.1080/10412905.2015.1133458]
[76]
Stoilova IS, Wanner J, Jirovetz L, et al. Chemical composition and antioxidant properties of juniper berry (Juniperus communis L.) essential oil. Bulg J Agric Sci 2014; 20: 227-34.
[77]
Guleria S, Kumar A, Tiku AK. Chemical composition and fungitoxic activity of essential oil of Thuja orientalis L. grown in the north-western Himalaya. Z Naturforsch C 2008; 63: 211-4.
[http://dx.doi.org/10.1515/znc-2008-3-409]
[78]
Rostaefar A, Hassani A, Sefidkon F. Seasonal variations of essential oil content and composition in male and female plants of Juniperus communis L. ssp. hemisphaerica growing wild in Iran. J Essent Oil Res 2017; 29: 357-60.
[http://dx.doi.org/10.1080/10412905.2017.1279990]
[79]
Chizzola R, Hochsteiner W, Hajek S. GC analysis of essential oils in the rumen fluid after incubation of Thuja orietalis twigs in the Rusitec system. Res Vet Sci 2004; 76: 77-82.
[http://dx.doi.org/10.1016/j.rvsc.2003.07.001]
[80]
Mllhau G, Valentin A, Benoit F, et al. In vitro antimalarial activity of eight essential oils. J Essent Oil Res 1997; 9: 329-33.
[http://dx.doi.org/10.1080/10412905.1997.10554252]
[81]
Tunalier Z, Kirimer N, Baser KHC. A potential new source of cedarwood oil: Juniperus foetidissima Willd. J Essent Oil Res 2004; 16: 233-5.
[http://dx.doi.org/10.1080/10412905.2004.9698707]
[82]
Appendino G, Cravotto G, Enriu R, et al. The chemistry and occurrence of taxane derivatives. Part 10. Rearranged taxanes from Taxus baccata. Phytochemistry 1994; 36: 407-11.
[http://dx.doi.org/10.1016/S0031-9422(00)97085-7]
[83]
Verdian-Rizi MR, Hadjiakhoondi A, Rezazadeh S, Dowlatabadi R, Pirali-Hamedani M. A new taxane diterpenoid from Taxus baccata growing in Iran. Chem Nat Compd 2010; 46: 377-9.
[http://dx.doi.org/10.1007/s10600-010-9621-6]
[84]
Das B, Rao SP, Srinivas KVNS, Yadav JS, Das R. A taxoid from needles of Himalayan Taxus baccata. Phytochemistry 1995; 38: 671-4.
[http://dx.doi.org/10.1016/0031-9422(94)00751-E]
[85]
Guo Y, Vanhaelen-Fastre R, Diallo B, et al. Immunoenzymic methods applied to the search for bioactive taxoids from Taxus baccata. J Nat Prod 1995; 58: 1015-23.
[http://dx.doi.org/10.1021/np50121a005]
[86]
Chattopadhyay SK, Sharma RP, Appendino G, Gariboldi P. A rearranged taxane from the Himalayan yew. Phytochemistry 1995; 39: 869-70.
[http://dx.doi.org/10.1016/0031-9422(95)00132-Q]
[87]
Poupat C, Ahond A, Potier P. New basic taxoid isolated from the leaves of Taxus baccata: 2-deacetyltaxine A. J Nat Prod 1994; 57: 1468-9.
[http://dx.doi.org/10.1021/np50112a023]
[88]
Barboni L, Gariboldi P, Appendino G, Enriu R, Gabetta B, Bombardelli E. The chemistry and occurrences of taxane derivatives. XVII. New taxoids from Taxus baccata L. Liebigs Ann 1995; 1995: 345-9.
[http://dx.doi.org/10.1002/jlac.199519950243]
[89]
Graf E, Berthodt H. Taxus alkaloids. II. Amorphous taxin and crystalline taxin A. Pharm Zentralhalle Dtschl 1957; 96: 385-95.
[90]
Guo Y, Diallo B, Jaziri M, Vanhaelen-Fastre R, Vanhaelen M, Ottinger R. Immunological detection and isolation of a new taxoid from the stem bark of Taxus baccata. J Nat Prod 1996; 59: 169-72.
[http://dx.doi.org/10.1021/np960043m]
[91]
Doss RP, Carney JR, Shanks CH, Williamson RT, Chamberlain JD. Two new taxoids from European Yew (Taxus baccata) that act as pyrethroid insecticide synergists with the black vine weevil (Otiorhynchus sulcatus). J Nat Prod 1997; 60: 1130-3.
[http://dx.doi.org/10.1021/np9703353]
[92]
Hadjiakhoondi A, Pirali-Hamedani M, Verdian-Rizi MR, Rezazadeh S. Taxane diterpenoids from Taxus baccata L. growing in Iran. J Med Pl 2009; 8(Suppl. 5): 39-44.
[93]
Mangoni L, Belardini M. Constituents of Cupressus sempervirens. II. Isolation and structure of two terpene ketones. Gazz Chim Ital 1966; 96: 206-19.
[94]
Kassem FF, Harraz FM, El‐Sebakhy NA, De Pooter HL, Schamp NM, Abou‐Shleib H. Composition of the essential oil of Egyptian Cupressus sempervirens L. cones. Flavour Fragrance J 1991; 6: 205-7.
[http://dx.doi.org/10.1002/ffj.2730060308]
[95]
Mangoni L, Belardini M. Isolation and structure of two diterpene 1,3-diones. Tetrahedron Lett 1964; 37: 2643-9.
[http://dx.doi.org/10.1016/S0040-4039(00)70401-1]
[96]
Asili J, Lambert M, Ziegler HL, et al. Labdanes and isopimaranes from Platycladus orientalis and their effects on erythrocyte membrane and on Plasmodium falciparum growth in the erythrocyte host cells. J Nat Prod 2004; 67: 631-7.
[http://dx.doi.org/10.1021/np034033e]
[97]
Kim CS, Choi SU, Lee KR. Three new diterpenoids from the leaves of Thuja orientalis. Planta Med 2012; 78: 485-7.
[http://dx.doi.org/10.1055/s-0031-1298215]
[98]
Kim TH, Li H, Wu Q, Lee HJ, Ryu J-H. A new labdane diterpenoid with anti-inflammatory activity from Thuja orientalis. J Ethnopharmacol 2013; 146: 760-. a
[http://dx.doi.org/10.1016/j.jep.2013.02.001]
[99]
Berkman MZ. Sakar MK, San Feliciano A, Del Olmo A. 3-α-acetoxy-trans-communic acid: a new labdane type diterpenoid from Juniperus excelsa Bieb. leaves. Acta Pharm Turcica 1994; 36: 64-7.
[100]
Muhammad I, Mossa JS, El‐Feraly FS. Antibacterial diterpenes from the leaves and seeds of Juniperus excelsa M. Bieb. Phytother Res 1992; 6: 261-4.
[http://dx.doi.org/10.1002/ptr.2650060508]
[101]
Bredenberg JBS. Ferruginol and Δ9-dehydroferruginol. Acta Chem Scand 1957; 11: 932-5.
[http://dx.doi.org/10.3891/acta.chem.scand.11-0932]
[102]
Janar J, Nugroho AE, Wong CP, et al. Sabiperones A-F, new diterpenoids from Juniperus sabina. Chem Pharm Bull (Tokyo) 2012; 60: 154-9. a
[http://dx.doi.org/10.1248/cpb.60.154]
[103]
De Pascual Teresa J, Barrero AF, Caballero MC, San Feliciano A. Components of Juniperus sabina L. berries. I. Hydrocarbons of essential oil. An Quim 1978; 74: 1093-6.
[104]
Tabacchi R, Garnero J, Buil P. Sur la présence d’un ester du décadiénol‐2(E), 4(Z) et de diterpènes dans l’huile essentielle de cyprès (Cupressus sempervirens L.). Helv Chim Acta 1975; 58: 1184-7.
[http://dx.doi.org/10.1002/hlca.19750580421]
[105]
San Feliciano A, Miguel del Corral JM, Gordaliza M, Angeles Castro M. Two diterpenoids from leaves of Juniperus sabina. Phytochemistry 1991; 30: 695-7. a
[http://dx.doi.org/10.1016/0031-9422(91)83757-C]
[106]
Koo KA, Sung SH, Kim YC. A new neuroprotective pinusolide derivative from the leaves of Biota orientalis. Chem Pharm Bull (Tokyo) 2002; 50: 834-6.
[http://dx.doi.org/10.1248/cpb.50.834]
[107]
Martin AM, Queiroz EF, Marston A, Hostettmann K. Labdane diterpenes from Juniperus communis L. berries. Phytochem Anal 2006; 17: 32-5.
[http://dx.doi.org/10.1002/pca.878]
[108]
Schneider I, Gibbons S, Bucar F. Inhibitory activity of Juniperus communis on 12(S)-HETE production in human platelets. Planta Med 2004; 70: 471-4.
[http://dx.doi.org/10.1055/s-2004-818980]
[109]
Khajjak MH, Raza AM, Shawani MN, Ahmed F, Shaheen G, Saeed M. Comparative analysis of essential oil contents of Juniperus excelsa (M. Beib.) found in Balochistan, Pakistan. Afr J Biotechnol 2012; 11: 8154-9.
[110]
Saab AM, Guerrini A, Sacchetti G, et al. Phytochemical analysis and cytotoxicity towards multidrug-resistant leukemia cells of essential oils derived from Lebanese medicinal plants. Planta Med 2012; 78: 1927-31.
[http://dx.doi.org/10.1055/s-0032-1327896]
[111]
Tomita B, Hirose Y, Nakatsuka T. Terpenoids. XVI. New constituents of Biota orientalis. Tetrahedron Lett 1968; 9: 843-8.
[http://dx.doi.org/10.1016/S0040-4039(01)98865-3]
[112]
Vernin G, Boniface C, Metzger J, et al. GC-MS-SPECMA bank analysis of Juniperus communis needles and berries. Phytochemistry 1988; 27: 1061-4.
[http://dx.doi.org/10.1016/0031-9422(88)80273-5]
[113]
Kim KH, Moon E, Kim SY, et al. Bioactive sesquiterpenes from the essential oil of Thuja orientalis. Planta Med 2013; 79: 1680-4. b
[http://dx.doi.org/10.1055/s-0033-1350952]
[114]
Madar Z, Gottlieb HE, Cojocaru M, Riov J, Solel Z, Sztejnberg A. Antifungal terpenoids produced by cypress after infection by Diplodia pinea f. sp. cupressi. Phytochemistry 1995; 38: 351-4.
[http://dx.doi.org/10.1016/0031-9422(94)00575-E]
[115]
Wang H. Extraction and identification of essential oil from Platycladus orientalis. Zhongcaoyao 2004; 35: 863.
[116]
Kirtany JK, Paknikar SK. Transformation products of 2-methyl-6-p-tolylhept-2-en-6-ol and comments on the assigned structure of curcumene ether. Indian J Chem 1974; 12: 1202-3.
[117]
Butkienë R, Nivinskienë O, Mockutë D. Volatile compounds of ripe berries (black) of Juniperus communis l. growing wild in North-East Lithuania. J Essent Oil-Bear Pl 2005; 8: 140-7.
[http://dx.doi.org/10.1080/0972060X.2005.10643434]
[118]
Haziri A, Faiku F, Mehmeti A, et al. Antimicrobial properties of the essential oil of Juniperus communis (L.) growing wild in east part of Kosovo. Am J Pharmacol Toxicol 2013; 8: 128-33.
[http://dx.doi.org/10.3844/ajptsp.2013.128.133]
[119]
Gonny M, Cavaleiro C, Salgueiro L, Casanova J. Analysis of Juniperus communis subsp. alpina needle, berry, wood and root oils by combination of GC, GC/MS and 13C-NMR. Flavour Fragrance J 2006; 21: 99-106.
[http://dx.doi.org/10.1002/ffj.1527]
[120]
Baggaley KH, Erdtman H, Norin T. Some new cedrane derivatives from Juniperus foetidissima willd. configuration of cedrolic acid. Tetrahedron 1968; 24: 3399-405.
[http://dx.doi.org/10.1016/S0040-4020(01)92637-7]
[121]
Thomas AF. 1,4-Dimethylcyclohex-3-enyl methyl ketone, a monoterpenoid with a novel skeleton. Helv Chim Acta 1973; 56: 1800-2.
[http://dx.doi.org/10.1002/hlca.19730560541]
[122]
Rawat P, Khan MF, Kumar M, et al. Constituents from fruits of Cupressus sempervirens. Fitoterapia 2010; 81: 162-6.
[http://dx.doi.org/10.1016/j.fitote.2009.08.014]
[123]
Janar J, Nugroho AE, Hirasawa Y, Konirhan B, Morita H. Sabinaperins A and B, two new lignans from Juniperus sabina. Heterocycles 2012; 84: 1259-63. b
[http://dx.doi.org/10.3987/COM-11-S(P)30]
[124]
San Feliciano A, Miguel Del Corral JM, Gordaliza M, Castro A. Acidic and phenolic lignans from Juniperus sabina. Phytochemistry 1991; 30: 3483-5. b
[http://dx.doi.org/10.1016/0031-9422(91)83240-L]
[125]
Feliciano AS, Miguel del Corral JM, Gordaliza M, Castro A. Lignans from Juniperus sabina. Phytochemistry 1990; 29: 1335-8.
[http://dx.doi.org/10.1016/0031-9422(90)85460-W]
[126]
Pohmakotr M, Komutkul T, Tuchinda P, Prabpai S, Kongsaeree P, Reutrakul V. Syntheses of (±)-thuriferic acid ethyl ester, its analogues and (±)-picropodophyllone. Tetrahedron 2005; 61: 5311-21.
[http://dx.doi.org/10.1016/j.tet.2005.03.069]
[127]
Guerrero E, Abad A, Montenegro G, Del Olmo E, López-Pérez JL, San Feliciano A. Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. Pharm Biol 2013; 51: 566-72.
[http://dx.doi.org/10.3109/13880209.2012.749921]
[128]
De Pascual J, San Feliciano A, Miguel del Corral JM, Barrero AF, Rubio M, Muriel L. 2,5-dimethylcoumarins from leaves of Juniperus sabina. Phytochemistry 1981; 20: 2778-9.
[http://dx.doi.org/10.1016/0031-9422(81)85289-2]
[129]
Lamer-Zarawska E. Phytochemical studies on flavonoids and other compounds of juniper fruits (Juniperus communis L.). Pol J Chem 1980; 54: 213-9.
[130]
Iida N, Inatomi Y, Murata H, et al. A new flavone xyloside and two new flavan-3-ol glucosides from Juniperus communis var. depressa. Chem Biodivers 2007; 4: 32-42.
[http://dx.doi.org/10.1002/cbdv.200790004]
[131]
Koriem KMM, Gad IB, Nasiry ZK. Protective effect of Cupressus sempervirens extract against indomethacin-induced gastric ulcer in rats. Interdiscip Toxicol 2015; 8: 25-34.
[http://dx.doi.org/10.1515/intox-2015-0006]
[132]
Al-Sayed E, Gad HA, El-Shazly M, Abdel-Daim MM, Nasser Singab A. Anti-inflammatory and analgesic activities of cupressuflavone from Cupressus macrocarpa: Impact on pro-inflammatory mediators. Drug Dev Res 2018; 79: 22-8.
[http://dx.doi.org/10.1002/ddr.21417]
[133]
Fan SY, Zeng HW, Pei YH, et al. The anti-inflammatory activities of an extract and compounds isolated from Platycladus orientalis (Linnaeus) Franco in vitro and ex vivo. J Ethnopharmacol 2012; 141: 647-52.
[http://dx.doi.org/10.1016/j.jep.2011.05.019]
[134]
Chae HS, Chin YW. Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells. Immunopharmacol Immunotoxicol 2012; 34: 250-5.
[http://dx.doi.org/10.3109/08923973.2011.600763]
[135]
Fan SY, Pei YH, Zeng HW, et al. Compounds from Platycladus orientalis and their inhibitory effects on nitric oxide and TNF-α production. Planta Med 2011; 77: 1623-30.
[http://dx.doi.org/10.1055/s-0030-1270905]
[136]
Kim JY, Kim HJ, Kim SM, et al. Methylene chloride fraction of the leaves of Thuja orientalis inhibits in vitro inflammatory biomarkers by blocking NF-kappaB and p38 MAPK signaling and protects mice from lethal endotoxemia. J Ethnopharmacol 2011; 133: 687-95.
[http://dx.doi.org/10.1016/j.jep.2010.10.051]
[137]
Lee YJ, Hwang SM, Yoon JJ, et al. Inhibitory effect of Thuja orientalis on TNF-α-induced vascular inflammation. Phytother Res 2010; 24: 1489-95.
[http://dx.doi.org/10.1002/ptr.3131]
[138]
Banfield AF. The wealth of India: a dictionary of Indian raw materials and industrial products (Industrial Products-Part I). Ind Med Gaz 1949; 84: 476-7.
[139]
Zhao J, Liu T, Xu F, You S, Li C, Gu Z. Anti-arthritic effects of total flavonoids from Juniperus sabina on complete freund’s adjuvant induced arthritis in rats. Pharmacogn Mag 2016; 12: 178-83.
[http://dx.doi.org/10.4103/0973-1296.186346]
[140]
Orhan N, Akkol E, Ergun F. Evaluation of anti-inflammatory and antinociceptive effects of some Juniperus species growing in Turkey. Turk J Biol 2012; 36: 719-26.
[141]
Kupeli E, Erdemoglu N, Yesilada E, Sener B. Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L. J Ethnopharmacol 2003; 89: 265-70.
[http://dx.doi.org/10.1016/j.jep.2003.09.005]
[142]
Dutta S, Mariappan G, Diapankar S, Sarkar P. Assessment of anti-inflammatory activity of Taxus baccata Linn. bark extract. Anc Sci Life 2010; 20: 19-21. a
[143]
Boussoussa H, Khacheba I, Berramdane T, Maamri A, Bendahgane H, Yousfi M. In vitro antidiabetic effect of saponins and phenolic extracts from fruits and seeds of Algerian cypress tree: Cupressus sempervirens L. Curr Enzym Inhib 2018; 14: 92-6.
[144]
Orhan N, Deliorman Orhan D, Gokbulut A, Aslan M, Ergun F. Comparative analysis of chemical profile, antioxidant, in vitro and in vivo antidiabetic activities of Juniperus foetidissima Willd. and Juniperus sabina L. Iran J Pharm Res 2017; 16: 64-74.
[145]
Erdemoglu N, Sener B, Choudhary MI. Bioactivity of lignans from Taxus baccata. Z Naturforsch C 2004; 59: 494-8.
[http://dx.doi.org/10.1515/znc-2004-7-807]
[146]
Amirnia M, Mokhtari F, Rezabakhsh A, et al. Cupressus sempervirens extract inhibited human basal cell carcinoma tumorigenesis, local invasion, and angiogenic property. Comp Clin Pathol 2017; 26: 203-11.
[http://dx.doi.org/10.1007/s00580-016-2370-6]
[147]
Emami SA, Sadeghi-Aliabadi H, Saeidi M, Jafarian A. Cytotoxic evaluations of Iranian conifers on cancer cells. Pharm Biol 2005; 43: 299-304.
[148]
Fayed SA. Chemical composition, antioxidant, anticancer properties and toxicity evaluation of leaf essential oil of Cupressus sempervirens. Not Bot Horti Agrobot Cluj-Napoca 2015; 43: 320-6.
[http://dx.doi.org/10.15835/nbha43210070]
[149]
Sadeghi-aliabadi H, Emami A, Saidi M, Sadeghi B, Jafarian A. Evaluation of in vitro cytotoxic effects of Juniperus foetidissima and Juniperus sabina extracts against a panel of cancer cells. Iran J Pharm Res 2009; 8: 281-6.
[150]
Darvishi M, Esmaeili S, Dehghan-Nayeri N, Mashati P, Gharehbaghian A. Anticancer effect and enhancement of therapeutic potential of vincristine by extract from aerial parts of Juniperus excelsa on pre-B acute lymphoblastic leukemia cell lines. J Appl Biomed 2017; 15: 219-26.
[151]
Topcu G, Erenler R, Cakmak O, et al. Diterpenes from the berries of Juniperus excelsa. Phytochemistry 1999; 50: 1195-9.
[152]
Rafieian-Kopaei M, Suleimani Dehkordi I, Ghanadian M, et al. Bioactivity-guided isolation of new antiproliferative compounds from Juniperus foetidissima Willd. Nat Prod Res 2016; 30: 1927-33.
[153]
Huyan T, Li Q, Wang YL, et al. Anti-tumor effect of hot aqueous extracts from Sonchus oleraceus L. and Juniperus sabina L. - Two traditional medicinal plants in China. J Ethnopharmacol 2016; 185: 289-99.
[154]
Tsai NM, Chang KF, Wang JC. Juniperus communis extract exerts antitumor effects in human glioblastomas through blood-brain barrier. Cell Physiol Biochem 2018; 49: 2443-62.
[155]
Vasilijević B, Knežević-Vukčević J, Mitić-Ćulafić D, et al. Chemical characterization, antioxidant, genotoxic and in vitro cytotoxic activity assessment of Juniperus communis var. saxatilis. Food Chem Toxicol 2018; 112: 118-25.
[http://dx.doi.org/10.1016/j.fct.2017.12.044]
[156]
Ghaly NS, Mina SA, Younis NAH. In vitro cytotoxic activity and phytochemical analysis of the aerial parts of Juniperus communis L. cultivated in Egypt. J Pharm Sci Res 2016; 8: 128-31.
[157]
Zhang J, Rahman A, Jain S, et al. Antimicrobial and antiparasitic abietane diterpenoids from Cupressus sempervirens. Res Rep Med Chem 2012; 21: 6.
[158]
Ibrahim TA, El-Hela AA, El-Hefnawy HM, Al-Taweel AM, Perveen S. Chemical composition and antimicrobial activities of essential oils of some coniferous plants cultivated in Egypt. Iran J Pharm Res 2017; 16: 328-37.
[159]
Khubeiz MJ, Mansour G, Zahraa B. Chemical composition and antimicrobial activity of the essential oil of Cupressus sempervirens L. leaves in Syria. Int J Toxicol Pharmacol Res 2016; 8: 281-6.
[160]
Eryilmaz M, Tosun A, Tümen I. Antimicrobial activity of some species from Pinaceae and Cupressaceae. Turkish J Pharm Sci 2016; 13: 35-40.
[http://dx.doi.org/10.5505/tjps.2016.43534]
[161]
Mazari K, Bendimerad N, Bekhechi C, Fernandez X. Chemical composition and antimicrobial activity of essential oils isolated from Algerian Juniperus phoenicea L. and Cupressus sempervirens L. J Med. Plant Res 2010; 4: 959-64.
[162]
Amouroux P, Jean D, Lamaison JL. Antiviral activity in vitro of Cupressus sempervirens on two human retroviruses HIV and HTLV. Phytother Res 1998; 12: 367-8.
[http://dx.doi.org/10.1002/(SICI)1099-1573(199808)12:5<367:AID-PTR301>3.0.CO;2-N]
[163]
Emami SA, Tayarani-Najaran Z, Sabouri Ghannad M, Khajeh Karamadini P, Khajeh Karamadini M. Antiviral activity of obtained extracts from different parts of Cupressus sempervirens against herpes simplex virus type 1. Iran J Basic Med Sci 2009; 12: 133-9.
[164]
Hassanzadeh MK, Rahimizadeh M, Fazly Bazzaz BS, Emami SA, Assili J. Chemical and antimicrobial studies of Platycladus orientalis essential oils. Pharm Biol 2001; 39: 388-90.
[http://dx.doi.org/10.1076/phbi.39.5.388.5894]
[165]
Gordien AY, Gray AI, Franzblau SG, Seidel V. Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae). J Ethnopharmacol 2009; 126: 500-5.
[http://dx.doi.org/10.1016/j.jep.2009.09.007]
[166]
Pepeljnjak S, Kosalec I, Kalodera Z, Blazevic N. Antimicrobial activity of juniper berry essential oil (Juniperus communis L., Cupressaceae). Acta Pharm 2005; 55: 417-22.
[167]
Moein MR, Ghasemi Y, Moein S, Nejati M. Analysis of antimicrobial, antifungal and antioxidant activities of Juniperus excelsa M. B subsp. polycarpos (K. Koch) Takhtajan essential oil. Pharmacol Res 2010; 2: 128-31.
[168]
Soković MD, Ristić M, Grubišić D. Chemical composition and antifungal activity of the essential oil from Juniperus excelsa berries. Pharm Biol 2004; 42: 328-31.
[http://dx.doi.org/10.1080/13880200490511936]
[169]
Asili J, Emami SA, Rahimizadeh M, Fazly-Bazzaz BS, Hassanzadeh MK. Chemical and antimicrobial studies of Juniperus communis subsp. hemisphaerica and Juniperus oblonga essential oils. J Essent Oil-Bear Pl 2008; 11: 96-105.
[http://dx.doi.org/10.1080/0972060X.2008.10643604]
[170]
Erdemoglu N, Sener B. Antimicrobial activity of the heartwood of Taxus baccata. Fitoterapia 2001; 72: 59-61.
[http://dx.doi.org/10.1016/S0367-326X(00)00233-1]
[171]
Krauze-Baranowska M, Wiwart M. Antifungal activity of biflavones from Taxus baccata and Ginkgo biloba. Z Naturforsch C 2003; 58: 65-9.
[http://dx.doi.org/10.1515/znc-2003-1-212]
[172]
De Campos RPO, Santos ARS, Vaz ZR, et al. Antinociceptive properties of the hydroalcholic extract and preliminary study of a xanthone isolated from Polgaya cyparissias. Life Sci 1997; 61: 1619-30.
[http://dx.doi.org/10.1016/S0024-3205(97)00741-8]
[173]
Miguel OG, Calixto JB, Santos AR, et al. Chemical and preliminary analgesic evaluation of geraniin and furosin isolated from Phyllanthus sellowianus. Planta Med 1996; 62: 192-7.
[http://dx.doi.org/10.1055/s-2006-957838]
[174]
Zaugg J, Khom S, Eigenmann D, Baburin I, Hamburger M, Hering S. Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice. J Nat Prod 2011; 74: 1764-72.
[http://dx.doi.org/10.1021/np200317p]
[175]
Koo KA, Kim SH, Lee MK, Kim YC. 15-Methoxypinusolidic acid from Biota orientalis attenuates glutamate-induced neurotoxicity in primary cultured rat cortical cells. Toxicol In Vitro 2006; 20: 936-41.
[http://dx.doi.org/10.1016/j.tiv.2006.02.001]
[176]
Kucukboyaci N, Orhan I, Sener B, Nawaz SA, Choudhary MI. Assessment of enzyme inhibitory and antioxidant activities of lignans from Taxus baccata L. Z Naturforsch C 2010; 65: 187-94.
[http://dx.doi.org/10.1515/znc-2010-3-404]
[177]
Dutta S, Yadav A, Mariappan G. Analgesic activity of Taxus baccata Linn. bark extract. Int J Pharma Bio Sci 2010; 1(1): 11b.
[178]
Al-Sayed E, Abdel-Daim MM. Protective role of Cupressuflavone from Cupressus macrocarpa against carbon tetrachloride-induced hepato- and nephrotoxicity in mice. Planta Med 2014; 80: 1665-71.
[http://dx.doi.org/10.1055/s-0034-1383211]
[179]
Ved A, Gupta A, Rawat AK. Antioxidant and hepatoprotective potential of phenol-rich fraction of Juniperus communis Linn. leaves. Pharmacogn Mag 2017; 13: 108-13.
[180]
Dwivedi SC, Shekhawat NB. Repellent effect of some indigenous plant extract against Trogoderma granarium (Everts). Asian J Exp Sci 2004; 18: 47-51.
[181]
Tapondjou AL, Adler C, Fontem DA, Bouda H, Reichmuth C. Bioactivities of cymol and essential oils of Cupressus sempervirens and Eucalyptus saligna against Sitophilus zeamais Motschulsky and Tribolium confusum du Val. J Stored Prod Res 2005; 41: 91-102.
[http://dx.doi.org/10.1016/j.jspr.2004.01.004]
[182]
Cannayane I, Banu GB. Allelochemic action of certain plant extracts on eggs and juveniles of Meloidogyn incognita. Curr Nematol 2002; 13: 83-9.
[183]
Patel PK, Patel KV, Gandhi TR. Evaluation of effect of Taxus baccata leaves extract on bronchoconstriction and bronchial hyperreactivity in experimental animals. J Young Pharm 2011; 3: 41-7.
[http://dx.doi.org/10.4103/0975-1483.76418]
[184]
Yang HO, Suh DY, Han BH. Isolation and characterization of platelet-activating factor receptor binding antagonists from Biota orientalis. Planta Med 1995; 61: 37-40.
[http://dx.doi.org/10.1055/s-2006-957995]
[185]
Yang HO, Han BH. Pinusolidic acid: A platelet-activating factor inhibitor from Biota orientalis. Planta Med 1998; 64: 73-4.
[http://dx.doi.org/10.1055/s-2006-957371]
[186]
Kim KA, Moon TC, Lee SW, Chung KC, Han BH, Chang HW. Pinusolide from the leaves of Biota orientalis as potent platelet activating factor antagonist. Planta Med 1999; 65: 39-42.
[http://dx.doi.org/10.1055/s-1999-13959]
[187]
Sepehrimanesh M, Samimi N, Koohi-Hosseinabadi O, Mokhtari M, Amiri-Zadeh S, Farjam M. Effects of Cupressus sempervirens extract on the healing of acetic acid-induced ulcerative colitis in rat. J Coloproctol (Rio J) 2018; 38: 309-13.
[http://dx.doi.org/10.1016/j.jcol.2018.07.002]
[188]
Ibrahim NA, El-Seedi HR, Mohammed MMD. Phytochemical investigation and hepatoprotective activity of Cupressus sempervirens L. leaves growing in Egypt. Nat Prod Res 2007; 21: 857-66.
[http://dx.doi.org/10.1080/14786410601132477]
[189]
Umezu T. Evaluation of the effects of plant-derived essential oils on central nervous system function using discrete shuttle-type conditioned avoidance response in mice. Phytother Res 2012; 26: 884-91.
[http://dx.doi.org/10.1002/ptr.3665]
[190]
Loizzo MR, Tundis R, Menichini F, Saab AM, Statti GA, Menichini F. Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells. Cell Prolif 2008; 41: 1002-2. b
[http://dx.doi.org/10.1111/j.1365-2184.2008.00561.x]
[191]
Abdel-Kader MS, Alanazi MT, Bin Saeedan AS, Al-Saikhan FI, Hamad AM. Hepatoprotective and nephroprotective activities of Juniperus sabina L. aerial parts. J Pharm Pharmacogn Res 2017; 5: 29-39.
[192]
Zhao J, Maitituersun A, Li C, Li Q, Xu F, Liu T. Evaluation on analgesic and anti-inflammatory activities of total flavonoids from Juniperus sabina. Evid Based Complement Alternat Med 2018 2018; 2018 7965306
[193]
Akkol EK, Güvenç A, Yesilada E. A comparative study on the antinociceptive and anti-inflammatory activities of five Juniperus taxa. J Ethnopharmacol 2009; 125: 330-6.
[http://dx.doi.org/10.1016/j.jep.2009.05.031]
[194]
Mahady GB, Pendland SL, Stoia A, et al. In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders. Phytother Res 2005; 19: 988-91.
[http://dx.doi.org/10.1002/ptr.1776]
[195]
Pramanik KC, Biswas R, Bandyopadhyay D, Mishra M, Ghost C, Chatterjee TK. Evaluation of anti-ulcer properties of the leaf extract of Juniperus communis L. in animals. J Nat Rem 2007; 7: 207-13.
[196]
Prakash AO. Biological evaluation of some medicinal plant extracts for contraceptive efficacy Future Aspects in Contraception. International Symposium. Heidelberg 5-8 September 1984. Contracept Deliv Syst 1984; 5: 9.
[197]
Yarnell E, Abascal K. Natural approaches to treating chronic prostatitis and chronic pelvic pain syndromes. Altern Complement Ther 2005; 11: 246-51.
[http://dx.doi.org/10.1089/act.2005.11.246]
[198]
Quintans LJ Jr, Almeida JRGS, Lima JT, et al. M. Plants with anticonvulsant properties - A review. Braz J Pharmacogn 2008; 18: 798-819.
[http://dx.doi.org/10.1590/S0102-695X2008000500026]
[199]
Hritcu L, Hancianu M, Mihasan M, Cioanca O. Effects of inhaled juniper volatile oil in amyloid beta (1-42)-induced anxiety and depression in laboratory rats. Flavour Fragrance J 2016; 31: 149-57.
[http://dx.doi.org/10.1002/ffj.3294]
[200]
Cioanca O, Mircea C, Trifan A, Aprotosoaie AC, Hriţcu L, Hǎncianu M. Improvement of amyloid-β-induced memory deficits by Juniperus communis L. volatile oil in a rat model of Alzheimer’s disease. Farmacia 2014; 62: 506-12.
[201]
Camporese A. In vitro activity of Eucalyptus smithii and Juniperus communis essential oils against bacterial biofilms and efficacy perspectives of complementary inhalation therapy in chronic and recurrent upper respiratory tract infections. Infez Med 2013; 21: 117-24.
[202]
Wojcikowski K, Wohlmuth H, Johnson DW, Rolfe M, Gobe G. An in vitro investigation of herbs traditionally used for kidney and urinary system disorders: Potential therapeutic and toxic effects. Nephrology (Carlton) 2009; 14: 70-9.
[http://dx.doi.org/10.1111/j.1440-1797.2008.01017.x]
[203]
Barzegarnejad A, Azadbakht M, Emadian O, Ahmadi M. Effect of some fractions of the extract of Juniperus communis fruit on solving kidney stones in vitro 2014; 23.


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VOLUME: 26
ISSUE: 14
Year: 2020
Page: [1584 - 1613]
Pages: 30
DOI: 10.2174/1381612826666200128100023
Price: $65

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