Access to a Library of 1,3-disubstituted-1,2,3-triazenes and Evaluation of their Antimicrobial Properties

Author(s): Insa Seck, Samba F. Ndoye, Lalla A. Ba, Alioune Fall, Abdoulaye Diop, Ismaïla Ciss, Abda Ba, Cheikh Sall, Amadou Diop, Cheikh S. Boye, Generosa Gomez, Yagamare Fall*, Matar Seck*

Journal Name: Current Topics in Medicinal Chemistry

Volume 20 , Issue 9 , 2020

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Graphical Abstract:


Background: Due to the rapid development of microbial resistance, finding new molecules became urgent to counteract this problem.

Objective: The objective of this work is to access 1,2,3-triazene-1,3-disubstituted, a class of molecule with high therapeutic potential.

Methods: Here we describe the access to 17 new triazene including six with an imidazole-1,2,3-triazene moiety and eleven with an alkyl-1,2,3-triazene moiety and their evaluation against five strains: two gram (-): Escherichia coli ATCC 25921 and Pseudomonas aeruginosa ATCC 27253; two gram (+) : Staphylococcus aureus ATCC 38213 and Enterococcus faecalis ATCC 29212; and one fungi: Candida albicans ATCC 24433.

Results: All strains were sensitive and the best MIC, 0.28 µM, is observed for 4c against Escherichia coli ATCC 25921. Compound 9, 3-isopropynyltriazene, appears to be the most interesting since it is active on the five evaluated strains with satisfactory MIC 0.32 µM against Escherichia coli and Pseudomonas aeruginosa and 0.64 µM against Enterococcus faecalis and Pseudomonas aeruginosa.

Conclusion: Comparing the structure activity relationship, electron withdrawing groups appear to increase antimicrobial activity.

Keywords: Strains, Resistance, Triazene, Antimicrobial, Minimal inhibitory concentrations, Bacterial infections.

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Article Details

Year: 2020
Page: [713 - 719]
Pages: 7
DOI: 10.2174/1568026620666200127143005
Price: $65

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