Quinoline Containing Side-chain Antimalarial Analogs: Recent Advances and Therapeutic Application

Author(s): Mukesh C. Joshi*, Timothy J. Egan

Journal Name: Current Topics in Medicinal Chemistry

Volume 20 , Issue 8 , 2020

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Graphical Abstract:


Abstract:

The side-chains of quinoline antimalarial agents are the major concern of focus to build novel and efficaciaous bioactive and clinical antimalarials. Bioative antimalarial analogs may play a critical role in pH trapping in the food vacuole of RBC’s with the help of fragmented amino acid, thus lead to β-hematin inhibition. Here, the authors tried to summarize a useful, comprehensive compilation of side-chain modified ACQs along with their synthesis, biophysical and therapeutic applications etc. of potent antiplasmodial agents and therefore, opening the door towards the potential clinical status.

Keywords: Chloroquine, P. falciparum, Antiplasmodial activity, β-HI activity, Cytotoxicity, Quinoline.

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VOLUME: 20
ISSUE: 8
Year: 2020
Page: [617 - 697]
Pages: 81
DOI: 10.2174/1568026620666200127141550
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