Objective: The aim of this study areto screen MicroRNAs (miRNAs) related to the prognosis of
lung adenocarcinoma (LUAD) and to explore the possible molecular mechanisms.
Methods: The data for a total of 535 patients with LUAD data were downloaded from The Cancer
Genome Atlas (TCGA) database. The miRNAs for LUAD prognosis were screened by both Cox risk
proportional regression model and Last Absolute Shrinkage and Selection Operator (LASSO) regression
model. The performances of the models were verified by time-dependent Receiver Operating
Characteristic (ROC) curve. The possible biological processes linked to the miRNAs’ target genes were
analyzed by Gene Ontology (GO), Kyoto gene and genome encyclopedia (KEGG).
Results: Among 127 differentially expressed miRNAs identified from the screening analysis, there are 111
up-regulated and 16 down-regulated miRNAs. Three of them, hsa-miR-1293, hsa-miR-490 and hsa-miR-
5571, were also significantly associated with the survival of the LUAD patients. The targets of the three
miRNAs are significantly enriched in systemic lupus erythematosus pathways.
Conclusion: Hsa-miR-1293, hsa-miR-490 and hsa-miR-5571 can be potentially used as novel biomarkers
for the prognosis prediction of LUAD.