Background: Natural products have been received attention due to their importance in human life as
those are biologically active. In this review, there are some reports through different methods related to the
synthesis of the indolizidine 195B which was extracted from poisonous frog; however, due to respect nature,
the synthesis of natural compounds such as indolizidine has been attracted much attention among scientists and
Objective: This review discloses the procedures and methods to provide indolizidine 195B from 1989 to 2018
due to their importance as a natural product.
Conclusion: There are several methods to give rise to the indolizidine 195B as a natural product that is highly
active from the biological perspective in pharmaceutical chemistry. In summary, many protocols for the
preparations of indolizidine 195B from various substrates, several reagents, and conditions have been reported
from different aromatic and aliphatic.