Background: Hypersensitivity to nickel is a very common cause of allergic contact dermatitis
since this metal is largely present in industrial and consumer products as well as in some commonly
consumed foods, air, soil, and water. In nickel-sensitized individuals, a cell-mediated delayed hypersensitivity
response results in contact to dermatitis due to mucous membranes coming in long-term
contact with nickel-containing objects. This process involves the generation of reactive oxidative species
and lipid peroxidation-induced oxidative damage. Immunologically, the involvement of T helper
(h)-1 and Th-2 cells, as well as the reduced function of T regulatory cells, are of importance. The toxicity,
mutagenicity, and carcinogenicity of nickel are attributed to the generation of reactive oxygen species
and induction of oxidative damage via lipid peroxidation, which results in DNA damage.
Objective: The aim of this research is to identify nutritionally actionable interventions that can intercept
nickel-induced cell damage due to their antioxidant capacities.
Conclusion: Nutritional interventions may be used to modulate immune dysregulation, thereby intercepting
nickel-induced cellular damage. Among these nutritional interventions are a low-nickel diet
and an antioxidant-rich diet that is sufficient in iron needed to minimize nickel absorption. These dietary
approaches not only reduce the likelihood of nickel toxicity by minimizing nickel exposure but
also help prevent oxidative damage by supplying the body with antioxidants that neutralize free radicals.