Background: LncRNA DLEU1 participates in various biological processes, playing an indispensable
role in the pathophysiology of human diseases, especially in tumorigenesis and other processes. Besides, it may
represent a promising target for biotherapy in numerous tumors. The aim of this review was to reveal the pathophysiological
functions and mechanisms of lncRNA DLEU1 in different types of cancer.
Methods: In this review, current studies concerning the biological functions and mechanisms of DLEU1 in tumor
development are summarized and analyzed; the related researches are collected through a systematic retrieval of
Results: DLEU1 is a novel cancer-associated lncRNA that has been proved to be abnormally elevated in various
malignancies, containing osteosarcoma, glioma, glioblastoma multiforme, hepatocellular carcinoma, bladder
cancer, cervical cancer, non-small cell lung cancer, pancreatic ductal adenocarcinoma, colorectal cancer, oral
squamous cell carcinoma, endometrial cancer, gastric cancer, Burkitt lymphoma and ovarian carcinoma. Besides,
lncRNA LDEU1 has been demonstrated involving in the procession of proliferation, migration, invasion and
inhibition of apoptosis of cancer cells.
Conclusion: Long non-coding RNA DLEU1 is likely to represent an available biomarker or a potential therapeutic
target in multiple tumors.