The Role of Heat Shock Protein -90 (HSP-90) in Inflammatory Disorders

Author(s): Chiranjib Bhattacharjee, Lokesh Deb*

Journal Name: Current Chemical Biology

Volume 14 , Issue 1 , 2020

DOI : 10.2174/2212796814666200122114833

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Abstract:

In human cells, Heat Shock Protein-90 (HSP-90) is present in the cytosol, nucleoplasm, endoplasmic reticulum, and mitochondria. The eukaryotic HSP-90 is multifunctionary and essential for cell viability, signal transduction, cell-cycle control as well as transcriptional regulation. The intracellular environment does not restrict HSP-90. It has a vital role in all types of inflammatory disorders, including cancer, autoimmune diseases, infectious inflammatory conditions. Hence, pharmacological inhibition of HSP-90 is currently a choice of therapeutic target for the treatment of autoimmune diseases, cancer, and infectious diseases. Based on the biology of HSP-90, several COOH-terminal ATPase sites of HSP-90, NH2-terminal ATPase sites of HSP-90, and Histone deacetylase inhibitors are evaluated and classified under various groups. For the treatment of different inflammatory disorders, HSP-90 identified as a promising therapeutic target. The present review may guide researchers for evaluating the HSP-90 targeted pathway as a useful therapeutic target for inflammatory diseases, including cancers.

Keywords: Heat shock protein-90 (HSP-90), autoimmune diseases, cancer, HSP inhibitor, viral HSP-90, fungal HSP-90.

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Article Details

VOLUME: 14
ISSUE: 1
Year: 2020
Published on: 27 May, 2020
Page: [30 - 37]
Pages: 8
DOI: 10.2174/2212796814666200122114833

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