Background: Pathogens use multiple mechanisms to disrupt cell functioning in their host
and allow pathogenesis. These mechanisms involve communication between the pathogen and the host
cell through protein-protein interactions.
Methods: Protein-protein interactions chains referred to as signal transduction pathways are the processes
by which a chemical or physical signal transmits through a cell as series of molecular events so
the pathogen needs to intercept these molecular pathways at few positions to induce pathogenesis such
as pathogen viability, infection or hypersensitivity.
Results: The pathogen nodes of interception are not necessarily the most immunogenic; so that novel
immunogenicity-improvement strategies need to be developed thought a chemical conjugation of the
pathogen-carrier nodes to develop an efficient immune response in order to block pathogenesis. On the
other hand, if pathogen-carriers are immunogens; toleration ought to be induced by this conjugation
avoiding hypersensitivity. Thus, this paper addresses the biological plausibility of plant-phenolics as
pathogen-carrier immunogenicity modulator haptens.
Conclusion: The plant-phenolic compounds have in their structure functional groups such as hydroxyl,
carbonyl, carboxyl, ester, or ether, capable of reacting with the amino or carbonyl groups of the amino
acids of a pathogen-carrier to form conjugates. Besides, the varied carbon structures these phenolic
compounds have; it is possible to alter the pathogen-carrier related factors that determine the immunogenicity:
1) Structural complexity, 2) Molecular size, 3) Structural heterogeneity, 4) Accessibility to
antigenic determinants or epitopes, 5) Optical configuration, 6) Physical state, or 7) Molecular rigidity.