Background: Near to 5-7 million people are infected with T. cruzi in the world, and
about 10,000 people per year die of problems associated with this disease.
Methods: Herein, the synthesis, antitrypanosomal and antimycobacterial activities of seventeen
coumarinic N-acylhydrazonic derivatives have been reported.
Results: These compounds were synthesized using methodology with reactions global yields ranging
from 46%-70%. T. cruzi in vitro effects were evaluated against trypomastigote and amastigote,
forming M. tuberculosis activity towards H37Rv sensitive strain and resistant strains.
Discussion: Against T. cruzi, the more active compounds revealed only moderate activity
IC50/96h~20 μM for both trypomastigotes and amastigotes intracellular forms. (E)-2-oxo-N'-
(3,4,5-trimethoxybenzylidene)-2H-chromene-3-carbohydrazide showed meaningful activity in
INH resistant/RIP resistant strain.
Conclusion: These compound acting as multitarget could be good leads for the development of
new trypanocidal and bactericidal agents.