Epilepsy is a neurological disorder that involves abnormal and recurrent neuronal discharges,
producing epileptic seizures. Recently, it has been proposed that the Wnt signaling pathway is essential
for the central nervous system development and function because it modulates important processes
such as hippocampal neurogenesis, synaptic clefting, and mitochondrial regulation. Wnt/β-
catenin signaling regulates changes induced by epileptic seizures, including neuronal death. Several
genetic studies associate Wnt/β-catenin signaling with neuronal excitability and epileptic activity. Mutations
and chromosomal defects underlying syndromic or inherited epileptic seizures have been identified.
However, genetic factors underlying the susceptibility of an individual to develop epileptic seizures
have not been fully studied yet. In this review, we describe the genes involved in neuronal excitability
in epileptogenic zones dependent on the Wnt/β-catenin pathway.