Importance of Pharmacist in Oxaliplatin Hepatotoxicity Associated with Inadequate Nutritional Diet: Case Report

Author(s): Iago D.L. Cavalcanti*, Diogo T. Costa, Andreza T. de Aguiar Silva, Adrya L. Peres, Cynthia G. de Oliveira Coimbra

Journal Name: Current Nutrition & Food Science

Volume 16 , Issue 5 , 2020

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Graphical Abstract:


A 40 years old male with colorectal cancer, with an unbalanced hypercaloric diet, attempted, on his own initiative, to gain weight, without nutritional follow-up, during chemotherapy treatment with oxaliplatin protocols, without pharmaceutical guidance. When initiating the new protocol, with oxaliplatin/irinotecan combination therapy, he presented symptomatology suggestive of hepatic injury during the administration of oxaliplatin. When performing a Magnetic Resonance Imaging of the total abdomen, hepatic nodules were identified indicating lesions resulting from the chemotherapy treatment, and blood tests indicated Aspartate aminotransferase levels in 55 U/L and Alanine aminotransferase in 68 U/L. The patient underwent partial hepatectomy for the removal of the nodules and was currently in clinical care, presenting a frame stable but non-therapeutic possibility. This case highlights the importance of interaction among health professionals, reinforcing the need for multiprofessional approaches to better patient response to antineoplastic treatment.

Keywords: Antineoplastic agents, chemical and drug-induced liver injury, combination, drug therapy, drug-related side effects and adverse reactions, hepatotoxicity, overnutrition, oxaliplatin.

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Year: 2020
Page: [839 - 844]
Pages: 6
DOI: 10.2174/1573401316666200120110632
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