Background: The benzimidazoles and benzothiazoles have shown relatively high pharmaceutical
and biological activities. In recent years, numerous methods have been developed for synthesis of
benzimidazole and benzothiazole derivatives using different catalysts. However, only some of the reported
procedures are quite satisfactory and most of them have drawbacks. Herein, we report a convenient method for
synthesis of benzimidazole and benzothiazole derivatives using a nickel (II) metal-organic framework (Ni-
MOF) as a novel and reusable catalyst. The presence of unsaturated metal centers makes metal-organic
frameworks to be used as Lewis acid catalysts.
Objective: The primary objective of this study was to describe an efficient method for synthesis of
benzimidazole and benzothiazole derivatives.
Method: Ni-MOF was prepared using the modified evaporation method and was characterized by FE-SEM,
FT-IR, TGA, and XRD techniques.The catalyst was then used to test the synthesis of some benzimidazole and
benzothiazole derivatives. The benzimidazoles and benzothiazoles were characterized by Elemental analyses,
HNMR and IR techniques.
Result: A variety of aromatic aldehydes bearing electron donating groups or electron-withdrawing were
reacted with 1,2-phenylenediamine or 2-aminothiophenol using Ni-MOF in good to excellent yields.
Conclusion: In summary, a new and highly efficient method was developed and reported for the synthesis of
benzimidazole and benzothiazole derivatives using nickel(II) metal-organic framework. The advantages are
short reaction times, good to excellent yields, the environmentally benign and simple procedure, stability, nontoxicity,
recyclability, and easy separation of the catalyst.