The oral bioavailability enhancement of poorly water-soluble medicaments is still one of the
most complicated aspects of the formulation development. Various approaches are currently available
for solubility and rate of dissolution enhancement such as salt formation, solubilization and reduction of
particle size, each with its own limitations and advantages. Solid dispersion is one of the most suitable
approaches for the formulation development of poorly water-soluble drugs. The popularity of solid
dispersion is evident from the increasing number of patent applications and patents granted in this field
during recent years. This article reviews the various approaches for the preparation of solid dispersion
such as a solvent melting, hot-melt extrusion method, solvent evaporation method, cryogenic processing
approaches etc. from the perspective of patents filed or granted for these techniques. Some of the
aspects taken into account before the preparation of solid dispersions are carrier selection and physicchemical
testing along with an insight into the molecular arrangement of medicaments in solid dispersion.
The manuscript further highlights various commercial patented technology platforms such as
Solumertm, Hovione and Kinetisol which are based on the concept of solid dispersions.
Keywords: Solid dispersion, patents, dissolution, bioavailability, solubility, patented platform, carrier.
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