Objective: To study the clinical and laboratory features of Antiphospholipid Syndrome
(APS) in a cohort of Egyptian patients and compare between primary and secondary type on the basis
of clinical and immunological pattern.
Patients and Methods: We reviewed the medical records of 148 antiphospholipid syndrome patients
following in Rheumatology and Rehabilitation department, Cairo University. Clinical and
immunological data were recorded; subsequently, our patients were compared based on the type of
APS, patient’s age and sex.
Results: The cohort consisted of 148 patients, 135 females (91.2%) and 13 males (8.8%). The mean
age at onset was 23.6 ±7.66 years. 28.4% of patients had primary while, 71.6% of patients had secondary
Patients with secondary APS presented more frequently with the following manifestations compared
to patients with primary APS: systemic manifestations (56.6% versus 4.8%, P-value: 0.00),
venous thrombosis (41.5% versus 19%, P-value: 0.009), cutaneous vasculitis (19.8% versus 4.8%,
P-value: 0.023), thrombocytopenia (37.7% versus 11.9%, P-value: 0.002) and hemolytic anemia
(28.3% versus 4.8%, P-value: 0.002). On the other hand, total obstetric manifestations were more
common in primary APS (92.5% versus 75%, P-value: 0.007).
Juvenile onset APS presented more frequently with systemic (68.8%, p-value: 0.02), neurological
(62.5%, p-value: 0.01) and renal manifestations (31.3%, p-value: 0.005). No statistically significant
difference was found between males and females in our cohort.
Conclusion: APS has broad spectrum manifestations, which may vary according to the patient’s
age at disease onset and association with other diseases. Further more, different ethnicities may
show different presentations.