Infants born prematurely (before completion of 37 weeks of gestation) are at increased
risk of morbidity and mortality due to vaccine preventable diseases, mostly because of their immunological
immaturity and failure of transfer of maternal protective antibodies. Despite their great
need of being vaccinated, concerns on vaccine safety and efficacy, constitute the main reasons for
which vaccinations are often delayed in this group. In this review we summarize the latest evidence
on vaccine safety, efficacy and immunogenicity in preterm infants which is similar to full-term infants.
Therefore there is no reason for delaying vaccination in this population.
Keywords: Vaccinations, immunization, premature infants, born, morbidity, mortality, immunogenicity.
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