Objective: Paeonol is a phenolic compounce that is volatile. In order to decrease its volatility
and achieve controlled release, paeonol-loaded liposome in carbomer hydrogel was prepared by coating
with soybean phospholipid via ethanol injection method and then added into the carbomer hydrogel.
Methods: The quality of paeonol-loaded liposome in carbomer hydrogel was evaluated by the degree of
roundness, particle size distribution, zeta potential, entrapment efficiency (filtration method and chitosan
neutralization method), viscosity, infrared spectrum, etc. Furthermore, the diffusion from paeonolloaded
liposome in hydrogel was studied in vitro.
Results: The results showed that the average particle size of paeonol-loaded liposome was about 401
nm, the potential was -17.8 mV, and the entrapment efficiency was above 45%. The viscosity of paeonol-
loaded liposome in hydrogel was 23.972×10-3 Pa*s, and the diffusion rate from paeonol-loaded
liposome in hydrogel in vitro was obviously slower than that from the other paeonol preparations.
Conclusion: The conclusions could be drawn that paeonol-loaded liposome in hydrogel was a kind of
novel preparation, and its diffusion in vitro had obvious controlled-release characteristics, which further
proved that it might improve the bioavailability of paeonol.