1-Deoxynojirimycin and its Derivatives: A Mini Review of the Literature

Author(s): Haijun Wang, Yin Shen, Lei Zhao*, Youfan Ye

Journal Name: Current Medicinal Chemistry

Volume 28 , Issue 3 , 2021


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Abstract:

1-Deoxynojirimycin (1-DNJ) is a naturally occurring sugar analogue with unique bioactivities. It is found in mulberry leaves and silkworms, as well as in the metabolites of certain microorganisms, including Streptomyces and Bacillus. 1-DNJ is a potent α-glucosidase inhibitor and it possesses anti-hyperglycemic, anti-obese, anti-viral and anti-tumor properties. Some derivatives of 1-DNJ, like miglitol, miglustat and migalastat, were applied clinically to treat diseases such as diabetes and lysosomal storage disorders. The present review focused on the extraction, determination, pharmacokinetics and bioactivity of 1-DNJ, as well as the clinical application of 1-DNJ derivatives.

Keywords: 1-deoxynojirimycin, metabolites, miglitol, miglustat, imino sugars, glucosidase inhibitors.

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Article Details

VOLUME: 28
ISSUE: 3
Year: 2021
Published on: 01 February, 2021
Page: [628 - 643]
Pages: 16
DOI: 10.2174/0929867327666200114112728
Price: $65

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