Title:1-Deoxynojirimycin and its Derivatives: A Mini Review of the Literature
VOLUME: 28 ISSUE: 3
Author(s):Haijun Wang, Yin Shen, Lei Zhao* and Youfan Ye
Affiliation:Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, Department of Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei
Keywords:1-deoxynojirimycin, metabolites, miglitol, miglustat, imino sugars, glucosidase inhibitors.
Abstract:1-Deoxynojirimycin (1-DNJ) is a naturally occurring sugar analogue with unique bioactivities.
It is found in mulberry leaves and silkworms, as well as in the metabolites of certain microorganisms,
including Streptomyces and Bacillus. 1-DNJ is a potent α-glucosidase inhibitor and it possesses
anti-hyperglycemic, anti-obese, anti-viral and anti-tumor properties. Some derivatives of 1-DNJ, like
miglitol, miglustat and migalastat, were applied clinically to treat diseases such as diabetes and
lysosomal storage disorders. The present review focused on the extraction, determination, pharmacokinetics
and bioactivity of 1-DNJ, as well as the clinical application of 1-DNJ derivatives.
