The delivery of drugs, via different layers of skin, is challenging because it acts as a natural barrier and
exerts hindrance against molecules to permeate into or through it. To overcome such obstacles, different noninvasive
methods, like vehicle-drug interaction, modifications of the horny layer and nanoparticles have been
suggested. The aim of the present review is to highlight some of the non-invasive methods for topical, diadermal
and transdermal delivery of drugs. Special emphasis has been made on the information available in numerous
research articles that put efforts in overcoming obstacles associated with barrier functions imposed by various
layers of skin. Advances have been made in improving patient compliance that tends to avoid hitches involved in
oral administration. Of particular interest is the use of lipid-based vesicles and nanoparticles for dermatological
applications. These particulate systems can effectively interact and penetrate into the stratum corneum via lipid
exchange and get distributed in epidermis and dermis. They also have the tendency to exert a systemic effect by
facilitating the absorption of an active moiety into general circulation.
Keywords: Diadermal, lipid vesicles, nanoparticles, non-invasive, topical, transdermal.
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