Marine Natural Products with High Anticancer Activities

Dario       Matulja; Karlo       Wittine; Nela       Malatesti; Sylvain       Laclef; Maris       Turks; Maria    Kolympadi    Markovic; Gabriela       Ambrožić; Dean       Marković
Abstract

This review covers recent literature from 2012-2019 concerning 170 marine natural products and their semisynthetic analogues with strong anticancer biological activities. Reports that shed light on cellular and molecular mechanisms and biological functions of these compounds, thus advancing the understanding in cancer biology are also included. Biosynthetic studies and total syntheses, which have provided access to derivatives and have contributed to the proper structure or stereochemistry elucidation or revision are mentioned. The natural compounds isolated from marine organisms are divided into nine groups, namely: alkaloids, sterols and steroids, glycosides, terpenes and terpenoids, macrolides, polypeptides, quinones, phenols and polyphenols, and miscellaneous products. An emphasis is placed on several drugs originating from marine natural products that have already been marketed or are currently in clinical trials.
Keywords: Anticancer, antitumor, cytotoxic, marine, medicinal chemistry, natural products.
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DOI https://dx.doi.org/10.2174/0929867327666200113154115	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
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