Marine Natural Products with High Anticancer Activities

Author(s): Dario Matulja, Karlo Wittine, Nela Malatesti, Sylvain Laclef, Maris Turks, Maria Kolympadi Markovic, Gabriela Ambrožić, Dean Marković*

Journal Name: Current Medicinal Chemistry

Volume 27 , Issue 8 , 2020


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Abstract:

This review covers recent literature from 2012-2019 concerning 170 marine natural products and their semisynthetic analogues with strong anticancer biological activities. Reports that shed light on cellular and molecular mechanisms and biological functions of these compounds, thus advancing the understanding in cancer biology are also included. Biosynthetic studies and total syntheses, which have provided access to derivatives and have contributed to the proper structure or stereochemistry elucidation or revision are mentioned. The natural compounds isolated from marine organisms are divided into nine groups, namely: alkaloids, sterols and steroids, glycosides, terpenes and terpenoids, macrolides, polypeptides, quinones, phenols and polyphenols, and miscellaneous products. An emphasis is placed on several drugs originating from marine natural products that have already been marketed or are currently in clinical trials.

Keywords: Anticancer, antitumor, cytotoxic, marine, medicinal chemistry, natural products.

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VOLUME: 27
ISSUE: 8
Year: 2020
Published on: 25 March, 2020
Page: [1243 - 1307]
Pages: 65
DOI: 10.2174/0929867327666200113154115
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