Title:Modification of Tumor Microenvironment Utilizing Nanotechnology Advancement for Better Therapeutic Effect
VOLUME: 10
Author(s):Dharmendra Kumar*, Pramod Kumar Sharma and Rishabha Malviya
Affiliation: Department of Pharmaceutics, SMAS, Galgotias University, Department of Pharmaceutics, SMAS, Galgotias University, Department of Pharmaceutics, SMAS, Galgotias University
Keywords:Breast cancer; tumor microenvironment; nanoparticles; cancer therapy.
Abstract:To study an in-depth overview of tumor microenvironment, its target sites and the impact
of nanoformulation in the modulation of tumor microenvironment specifically in the case of
breast cancer as a treatment strategy.
Tumor microenvironment has many sites for possible action such as extracellular matrix, acidic
pH, vascular abnormalities, etc. Nanoformulation may change tumor microenvironment via targeting
these sites and help to treat cancer. Various types of cancer were treated through this mechanism
and discussed in this manuscript. In the future, discussed mechanisms may play a pivotal role
to develop new nano-drug delivery for cancer therapy.
It can be concluded after extensive literature survey that nanoformulation is able to modulate tumor
microenvironment specifically in case of breast cancer which leads to beneficial therapeutic
effect against tumor growth. Improved understanding of this relation (nano-formulation and tumor
microenvironment) may provide many ideas to develop new nanoformulation for breast cancer
treatment.
