To study an in-depth overview of tumor microenvironment, its target sites and the impact
of nanoformulation in the modulation of tumor microenvironment specifically in the case of
breast cancer as a treatment strategy. Tumor microenvironment has many sites for possible action
such as extracellular matrix, acidic pH, vascular abnormalities, etc. Nanoformulation may change
tumor microenvironment via targeting these sites and help to treat cancer. Various types of cancer
were treated through this mechanism and discussed in this manuscript. In the future, discussed
mechanisms may play a pivotal role to develop new nano-drug delivery for cancer therapy. It can
be concluded after extensive literature survey that nanoformulation is able to modulate tumor microenvironment
specifically in case of breast cancer which leads to beneficial therapeutic effect
against tumor growth. Improved understanding of this relation (nano-formulation and tumor microenvironment)
may provide many ideas to develop new nanoformulation for breast cancer treatment.
Keywords: Breast, cancer, tumor, microenvironment, nanoparticles, cancer therapy.
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