Title:Nanotechnology-based Targeting of Neurodegenerative Disorders: A Promising Tool for Efficient Delivery of Neuromedicines
VOLUME: 21 ISSUE: 8
Author(s):Kuldeep Rajpoot*
Affiliation:Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, 495 009, Chhattisgarh
Keywords:Neurodegenerative disorders, amyloid-β peptide, parkinson's disease, nanoparticles, nanotechnology, alzheimer's
disease.
Abstract:Traditional drug delivery approaches remained ineffective in offering better treatment to
various neurodegenerative disorders (NDs). In this context, diverse types of nanocarriers have shown
their great potential to cross the blood-brain barrier (BBB) and have emerged as a prominent carrier
system in drug delivery. Moreover, nanotechnology-based methods usually involve numerous nanosized
carrier platforms, which potentiate the effect of the therapeutic agents in the therapy of NDs especially
in diagnosis and drug delivery with negligible side effects. In addition, nanotechnology-based
techniques have offered several strategies to cross BBB to intensify the bioavailability of drug moieties
in the brain. In the last few years, diverse kinds of nanoparticles (NPs) have been developed by
incorporating various biocompatible components (e.g., polysaccharide-based NPs, polymeric NPs, selenium
NPs, AuNPs, protein-based NPs, gadolinium NPs, etc.), that showed great therapeutic benefits
against NDs. Eventually, this review provides deep insights to explore recent applications of some innovative
nanocarriers enclosing active molecules for the efficient treatment of NDs.