A Brief Overview on HIV Infection, Diagnosis and Treatment

Author(s): Mrinmoy Saha*, Shreya Bhattacharya*

Journal Name: Current Topics in Medicinal Chemistry

Volume 19 , Issue 30 , 2019

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Saha, M.; Bhattacharya, S. Recent developments in the medicinal chemistry for new small-molecule therapeutics to treat HIV-AIDS. Curr. Top. Med. Chem., 2019, 19(18), 1569-1570.
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Riddell, J.t.; Amico, K.R.; Mayer, K.H. HIV Preexposure prophylaxis: a review. JAMA, 2018, 319(12), 1261-1268.
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Zhan, P.; Pannecouque, C.; De Clercq, E.; Liu, X. Anti-HIV drug discovery and development: current innovations and future trends. J. Med. Chem., 2016, 59(7), 2849-2878.
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Hartman, T.L.; Yang, L.; Helfrick, A.N.; Hassink, M.; Shank, N.I.; George Rosenker, K.; Scerba, M.T.; Saha, M.; Hughes, E.; Wang, A.Q.; Xu, X.; Gupta, P.; Buckheit, R.W., Jr; Appella, D.H. Preclinical evaluation of a mercaptobenzamide and its prodrug for NCp7-targeted inhibition of human immunodeficiency virus. Antiviral Res., 2016, 134, 216-225.
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Saha, M.; Scerba, M.T.; Shank, N.I.; Hartman, T.L.; Buchholz, C.A.; Buckheit, R.W., Jr; Durell, S.R.; Appella, D.H. Probing mercaptoben- zamides as HIV inactivators via nucleocapsid protein 7. ChemMedChem, 2017, 12(10), 714-721.
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Nikolayevskiy, H.; Robello, M.; Scerba, M.T.; Pasternak, E.H.; Saha, M.; Hartman, T.L.; Buchholz, C.A.; Buckheit, R.W., Jr; Durell, S.R.; Appella, D.H. The structure-activity profile of mercaptobenzamides’ anti-HIV activity suggests that thermodynamics of metabolism is more important than binding affinity to the target. Eur. J. Med. Chem., 2019, 178, 818-837.
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Sancineto, L.; Iraci, N.; Tabarrini, O.; Santi, C. NCp7: targeting a multitasking protein for next-generation anti-HIV drug development part 1: covalent inhibitors. Drug Discov. Today, 2018, 23(2), 260-271.


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Article Details

VOLUME: 19
ISSUE: 30
Year: 2019
Published on: 03 January, 2020
Page: [2739 - 2741]
Pages: 3
DOI: 10.2174/156802661930200103091335

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