Multi-target drugs have gained considerable attention in the last decade owing to their
advantages in the treatment of complex diseases and health conditions linked to drug resistance.
Single-target drugs, although highly selective, may not necessarily have better efficacy or fewer
side effects. Therefore, more attention is being paid to developing drugs that work on multiple
targets at the same time, but developing such drugs is a huge challenge for medicinal chemists.
Each target must have sufficient activity and have sufficiently characterized pharmacokinetic parameters.
Multi-target drugs, which have long been known and effectively used in clinical practice,
are briefly discussed in the present article. In addition, in this review, we will discuss the
possible applications of multi-target ligands to guide the repositioning of prospective drugs.
Keywords: Multitarget drugs, Alzheimer's disease, Parkinson's disease, cancer, neglected tropical diseases,
Rights & PermissionsPrintExport