New Inhibition Detection Method to Evaluate the Human Salivary Alpha-amylase Activity of Some Drugs, Molecular Docking, and SAR Studies

(E-pub Ahead of Print)

Author(s): Nia Samira*, Benarous Khedidja, Lakaas Manel, Sadeki Israa, Yousfi Mohamed

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents)

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Background: For the first time, the investigation of six anti-inflammatory drugs and six antihistaminic drugs for inhibitory activities against alpha-amylase has been evaluated using a new inhibition detection method in order to find new treatments for some diseases caused by α-amylase.

Objective: The first part of this work was devoted to the evaluation of the inhibition activity of these drugs on salivary α-amylase in vitro. Then to study the nature of interactions and structure-activity relationship, using Autodockvina program for molecular docking.

Method: The evaluation of the inhibitory activity of our drugs is achieved using a new method that has proved its sensitivity, quickness and effectiveness.

Results: The results of this study show that the betamethasone and loratadine are potent α-amylase inhibitors with IC50 values 0.7mg/ml and 1.03 mg/ml, respectively compared to acarbose with IC50=5.6 µg/ml.

Conclusion: The results showed that the loratadine and the betamethasone have a strong potential to inhibit the alpha amylase.

Keywords: Inhibition activity, Human salivary α-amylase, Anti-inflammatory drugs, Antihistaminic drugs, Molecular docking

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(E-pub Ahead of Print)
DOI: 10.2174/1871523019666200102111048
Price: $95

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