Title:A Comprehensive Review on DNA Gyrase Inhibitors
VOLUME: 20 ISSUE: 6
Author(s):S.R. Chitra*, N. Ramalakshmi, Subramani Arunkumar and P. Manimegalai
Affiliation:Department of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai -97, Department of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai -97, College of Pharmacy, Gulf Medical University, Ajmaan, Department of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai -97
Keywords:DNA gyrase inhibitors, docking, antibacterial, anticancer, antimalarial, fungal infections.
Abstract:The newly emerging infectious organisms, the global crisis in antibiotic resistance, and
the threat of bioterrorism create an urgent need to discover novel antimicrobial agents. In order to
develop novel antimicrobial agents, the mechanism of infectious disease must be better understood.
DNA Gyrase is a bacterial enzyme that plays an important role in the replication of DNA
and transcription process. It is not present in higher eukaryotes making it a perfect target for developing
new antibacterial agents. This review describes the role of DNA gyrase inhibitors in
preventing various diseases. In this review, we outline the synthesis and pharmacological action of
various novel DNA gyrase inhibitors. DNA gyrase inhibitors were used to treat tuberculosis, bacterial,
fungal infections and malaria. DNA gyrase inhibitors mainly act by preventing the supercoiling
of DNA strands.
