Background: Effective cancer treatment is a major public health challenge. The limitations of
current therapies and their adverse effects reduce the efficacy of treatment, leading to significant mortality
rates worldwide. Moreover, natural product chemistry occupies a prominent role in the search for
new treatment alternatives, by contributing a spectrum of chemical structures that may potentially yield
new bioactive compounds. The compound -gingerol (1) is the main active substance in ginger
(Zingiber officinale) and several studies have shown it to produce beneficial effects, including antitumor
Objective: This work aims to obtain new gingerol derivatives with cytotoxic activity.
Methods: -gingerol was isolated and its derivatives were produced using click chemistry, obtaining
eight new compounds. All chemical structures were determined by means of IR, NMR and HRMS data,
and cytotoxicity was evaluated in the HCT 116 (colon carcinoma) and MCF-7 (breast carcinoma) cell
lines at concentrations of 5 µmol L-1 and 50 µmol L-1.
Results: At 50 µmol L-1, more than 70% inhibition of cell growth was achieved with compounds 2e, 2g
against HCT 116, and 2b, 2d, 2e, 2f and 2g against MCF-7.
Conclusion: The obtained compounds showed only moderate cytotoxic activity. However, the products
with substituents occupying the meta position in relation to the triazole ring showed increased cytotoxic
properties. The brominated compound (2g) showed the strongest activity, inhibiting cell proliferation by