Highly Selective Hydroiodination of Carbon-Carbon Double or Triple Bonds

(E-pub Ahead of Print)

Author(s): Yuki Yamamoto, Shin-ichi Kawaguchi, Shintaro Kodama, Akihiro Nomoto, Akiya Ogawa*

Journal Name: Current Organic Chemistry

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Iodine is an element that exhibits characteristic features of heavy halogen, and several compounds containing iodine constitute important synthetic intermediates due to synthetically easy manipulation. To utilize iodine units for organic synthesis, a highly regio- and stereoselective introduction of iodine to versatile building blocks is significant, and a lot of researches for the selective introduction of iodine to alkynes or alkenes have been investigated. In this review article, we describe regio- and stereoselective hydroiodination to multiple bonds of building blocks, and its synthetic applications as key intermediates to construct several important compounds in organic chemistry.

Keywords: Hydroiodination, regio- and stereoselective synthesis, alkene and alkyne activations, green synthesis, cross-coupling, iodine reagents

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1385272824666191227111257
Price: $95