Background: MicroRNA (miRNA) is a pivotal regulator of the occurrence and
development of various cancers. And gastric cancer (GC) is one of the most common
and deadly cancers in the world. The aim of this study is to explore whether the
microRNA-143 host gene (miR-143HG) polymorphisms are correlated with the risk of
Methods: 5 single-nucleotide polymorphisms (SNPs) were genotyped among 506
patients and 500 healthy controls in Han Chinese population. Multiple genetic models,
stratification analysis and haplotype analysis were used to evaluate the association
between miR-143HG polymorphisms and GC risk by calculating odds ratios (ORs), 95%
confidence intervals (CIs).
Results: Our results indicated that rs11168100 was associated with decreased risk of
GC under the Codominant model (OR = 0.67, 95%CI = 0.52-0.88, p = 0.003), and under
the Dominant model (OR = 0.72, 95%CI = 0.56-0.92, p = 0.009). Rs353300 was
associated with increased risk of GC under the Recessive model (OR = 1.41, 95%CI =
1.06-1.87, p = 0.017). Further, rs11168100 and rs353300 were correlated with the
susceptibility of GC (age > 60 years), and three SNPs (rs12654195, rs353303, and
rs353300) were related with the risk of GC (age ≤ 60 years). In addition, two SNPs
(rs12654195 and rs11168100) were found to be associated with decrease in the
susceptibility of GC in the female subgroup. Rs353300 represented two-sided roles in
the occurrence and development of GC in female. Finally, rs3533003 was associated
with decreased risk of GC in stratified analysis of lymph node metastasis.
Conclusion: For the first time, our results provide some evidence on the polymorphisms
of miR-143HG associated with GC risk in the Chinese Han population.