Objective: The prevalence of primary hypothyroidism is increasing in adults
(PHTA), and the reduction in the threshold for treatment and also the requirement to increase
drug usage are major problems in approaching this disorder. Persian Medicine (PM) has a
different view on the etiology of diseases. Therefore, the etiologies of PHTA according to an
important book of PM i.e., “Zakhire Kharazmshahi” are presented.
Method: At first, the common symptoms and signs of PHTA were identified by investigating
the Medline, Scopus, and Cochrane databases and their Persian equivalents were extracted
from PM sources. These synonyms were searched as keywords in the book and the primary
causes that were mentioned in association with the signs and symptoms were extracted.
Then, the total etiologies that were discussed for the occurrence of the causes, with respect to
the principles of health care in PM were explained.
Results: "Cold distemperament", an increase in "Phlegmatic Humor", an increase in "Melancholic
Humor" and "Emtela" (repletion) were recognized as four main causes of PHTA. According
to the book, the most important etiologies of these conditions are insufficient exercise,
overeating, food intake before total stomach emptying and excessive amounts of cold
temperament substances (foods, herbs, seeds, spices, etc.) in daily diet.
Conclusion: From the viewpoint of PM, lifestyle spatially eating habits and physical activity
play important causative roles in occurring and prognosis of PHTA. Hence, it is recommended
to assess these results by more observations and clinical studies.