Background: Perihematomal edema (PHE) is a major threat leading to poor functional
outcomes after intracerebral hemorrhage (ICH). TIMP-2 is considered to participate in the formation
of PHE after ICH by antagonizing the damaging effects of MMP-2. In the early study, the polymorphisms
of TIMP-2 rs8179090 have shown to influence the expression of TIMP-2.
Objective: To prove that the severity of PHE was different in ICH patients with different TIMP-2
Methods: In this prospective study, 130 hypertensive ICH patients were enrolled. The poly phisms
of rs8179090 in TIMP-2 were determined. The hematoma volume and PHE volume were measured
by computed tomography (CT) scan immediately after the onset of ICH, and were measured
again one week and two weeks after the onset. Then, the comparison of TIMP-2 rs8179090 genotypes
Results: TIMP-2-418 position (rs8179090) had two genotypes in the studied population, GC and
GG. Patients with the GC genotype developed more severe PHE, with a higher incidence of delayed
cerebral edema in cerebral hemorrhage than those with the GG genotype.
Conclusion: We have found that the GC genotype group may develop more severe PHE, with an
increased incidence of delayed cerebral edema in cerebral hemorrhage.