Recent Advancements in Biological Activities of Oxadiazole and their Derivatives: A Review

Author(s): Arun Kumar Mishra*, Arvind Kumar, Jagdish K. Sahu

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 6 , 2020

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Graphical Abstract:


Abstract:

Oxadiazole moiety, which is one of the heterocyclic aromatic groups of the azole family; with the molecular formula C2H2N2O, exists in four isomeric form; out of which, 1,2,4-oxadiazole; 1,2,5-oxadiazole and 1,3,4-oxadiazole are common isomers. The stable isomeric forms of oxadiazoles are observed in a variety of pharmaceutical important potent drugs including raltegravir, butalamine, fasiplon, oxolamine and pleconaril. An attempt has been made to emphasize the chemistry and pharmacology associated with oxadiazole and its derivatives. A number of oxadiazole derivatives are very popular and common in use as potential therapeutic agents. However, a number of researchers are working and have worked to find out more synthetic analogues for anticancer and antifungal, anti-HIV agents using biological and in-silico models.

Keywords: Oxadiazole, anti-bacterial activity, analgesic activity, anti-inflammatory activity, anti-convulsant activity, anticancer activity, anti-tubercular activity.

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Article Details

VOLUME: 17
ISSUE: 6
Year: 2020
Page: [409 - 429]
Pages: 21
DOI: 10.2174/1570178617666191220115426
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