Objective: To evaluate the plasma cytokine levels during T cell-mediated inflammatory
responses and compare the metabolic markers between overweight and obese perimenopausal women
without systemic diseases.
Methods: Sixty perimenopausal women were divided into two groups (overweight and obese). Participants
in both groups had their waist-to-height ratio (WHtR) measured and blood samples collected for
the evaluation of estradiol, fasting glucose, leptin, high-sensitivity C-reactive protein (hs-CRP), interleukin
(IL)-6, IL-10, IL-17A levels, and lipid profile.
Results: In univariate analysis, women with obesity showed increased WHtR, fasting glucose, leptin,
and IL-6 (p < 0.05) levels; however, significant differences were not observed in IL-10 or IL-17A (p >
0.05) levels. In the receiver operating characteristic curve, the highest areas under the curve were
shown for leptin (0.856) and IL-6 (0.706). IL-6 levels correlated with both hs-CRP (r = 0.302, p =
0.020) and leptin (r = 0.294, p = 0.022). However, in multivariate analysis, IL-6 was not associated
with a greater likelihood of obesity (OR = 1.61; 95% CI: 0.82-3.15; p = 0.16), when potential confounders
Conclusion: IL-6 levels varied between overweight and obese perimenopausal women, and this association
was weaker when adjusted for other clinical variables.