3,5-Bis(trifluoromethyl) Phenylammonium triflate(BFPAT) as a Novel Organocatalyst for the Efficient Synthesis of 2,3-dihydroquinazolin-4(1H)-one Derivatives

Author(s): Mandana Alipour, Zinatossadat Hossaini, Samad Khaksar*, Faramarz Rostami-Charati

Journal Name: Current Organic Synthesis

Volume 17 , Issue 1 , 2020

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Graphical Abstract:


Aims and Objectives: A one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives by threecomponent cyclo-condensation of isatoic anhydride, aldehydes and amine or ammonium acetate has been developed using 3,5-Bis(trifluoromethyl) phenylammonium triflate (BFPAT) as a new organocatalyst.

Materials and Methods: All of the obtained products are known compounds and identified by IR, 1HNMR, 13CNMR and melting points.

Results: A wide variety of structurally different aldehydes reacted easily and rapidly to result in the relating 2,3-dihydroquinazolin-4(1H)-ones in good to excellent yield.

Conclusion: We have demonstrated an extremely effective and new process for synthesizing 2,3- dihydroquinazolin-4(1H)-ones employing BFPAT as a novel organocatalyst in one-pot fashion.

Keywords: Organocatalyst, green chemistry, quinazoline, multicomponent, heterocyclic, antitumor, anti-diabetes.

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Year: 2020
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DOI: 10.2174/1570179417666191218115126
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