Background: Excessive blue light light-emitting diode (LED) exposure and consequent oxidative
stress causes corneal damage and corneal injuries are the major problem arising these days due to
excessive use of mobile phone, TV, environment pollution, etc.
Objective: In the present investigation, the protectiveness of carboxymethyl Terminalia catappa (CTC)
from blue light LED-induced corneal damage was explored.
Methods: For this purpose, Terminalia catappa (TC) was functionalized by carboxymethylation and its
structural modification was confirmed by spectral attributes. Further, the CTC protective eye drop formulations
(0.025-1%, w/v) were prepared and evaluated for their capability of protection from blue light
LEDinduced corneal damage as compared to CTC protective eye gel (1.25-7%, w/v). The findings
pointed towards excellent protection of CTC gel formulations as compared to CTC eye drop formulations.
In addition, the prepared optimized CTC gel had thixotropic behavior as evident from percentage
structural recovery which was 1.75 fold higher than marketed formulation (I-Comfort, HPMC 2%, w/v).
The safety and non-toxicity of CTC protective eye drop and gel were confirmed by HET-CAM test.
Further, a rat eye model was implemented that mimic blue light light-emitting diode induced corneal
damage in day to day life to assess the protective effect of CTC protective eye drop and gel.
Results: The order of protectiveness of CTC formulations was found to be CTC protective eye gel (4%,
w/v) (no corneal damage)>marketed eye gel (12.34% corneal damage)=CTC protective eye drop
(0.75%, w/v) (17.48% corneal damage)> marketed eye drop (51% corneal damage). The mechanism
behind the protective effect of CTC eye drop and gel was associated with good free radical scavenging
activity and corneal adhesive property of CTC. It is established from the present work that, carboxymethyl
Terminalia catappa has protective action against blue light light-emitting diode induced