Synthesis of C3-Quaternary 2H-Pyrrolines by [3+2] Cycloaddition of Isocyanoacetates and 1,1-Disubstituted Alkenes

Author(s): Yi Cheng, Runmei Zhang, Tianhao Lu, Yong Shen, Min Wang, Chunsong Xie*

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 8 , 2020

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Abstract:

Under mild conditions, C3-quaternary 2H-pyrrolines can be convergently and efficiently assembled by Cu(II) and weak bases cocatalyzed [3+2] cycloaddition of 1,1-disubstituted alkenes and isocyanoacetates. Various functionalities can be tolerated, affording 2H-pyrrolines with up to two quaternary centers in a single step.

Keywords: 2H-pyrroline, copper catalysis, isocyanoacetate, isonitrile, cycloaddition, quaternary carbon.

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Article Details

VOLUME: 17
ISSUE: 8
Year: 2020
Page: [586 - 589]
Pages: 4
DOI: 10.2174/1570178617666191218104959
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