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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Anti-inflammatory Constituents from Eurycoma longifolia Roots

Author(s): Nguyen Minh Chau, Ha Manh Tuan, Tran Manh Hung, Nguyen Tien Dat* and Nguyen Hai Dang

Volume 17, Issue 6, 2020

Page: [455 - 458] Pages: 4

DOI: 10.2174/1570178617666191218104241

Price: $65

Abstract

Eight secondary metabolites (1-8) were isolated from the roots of Vietnamese Eurycoma longifolia. The structures of these compounds were elucidated using a variety of spectroscopic methods. Among the compounds was eurylongilactone A (1), a new oxygenated C20 quassinoid with a 11β,20-epoxy bridge. The anti-inflammatory activities of the compounds were evaluated against LPSinduced NO production in RAW264.7 cells. Compound 1 and ethyl ferulate (8) had the strongest inhibitory effects, with IC50 values of 3.03 ± 0.73 and 3.56 ± 0.43 µM, respectively. Compounds 2, 4, and 7 had moderate activity.

Keywords: Eurycoma longifolia, Simaroubaceae, eurylongilactone A, quassinoid, NO production, anti-inflammation.

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