Eight secondary metabolites (1-8) were isolated from the roots of Vietnamese Eurycoma
longifolia. The structures of these compounds were elucidated using a variety of spectroscopic methods.
Among the compounds was eurylongilactone A (1), a new oxygenated C20 quassinoid with a
11β,20-epoxy bridge. The anti-inflammatory activities of the compounds were evaluated against LPSinduced
NO production in RAW264.7 cells. Compound 1 and ethyl ferulate (8) had the strongest inhibitory
effects, with IC50 values of 3.03 ± 0.73 and 3.56 ± 0.43 µM, respectively. Compounds 2, 4,
and 7 had moderate activity.
Keywords: Eurycoma longifolia, Simaroubaceae, eurylongilactone A, quassinoid, NO production, anti-inflammation.
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