Anti-inflammatory Constituents from Eurycoma longifolia Roots

Author(s): Nguyen Minh Chau, Ha Manh Tuan, Tran Manh Hung, Nguyen Tien Dat*, Nguyen Hai Dang.

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 6 , 2020

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Graphical Abstract:


Eight secondary metabolites (1-8) were isolated from the roots of Vietnamese Eurycoma longifolia. The structures of these compounds were elucidated using a variety of spectroscopic methods. Among the compounds was eurylongilactone A (1), a new oxygenated C20 quassinoid with a 11β,20-epoxy bridge. The anti-inflammatory activities of the compounds were evaluated against LPSinduced NO production in RAW264.7 cells. Compound 1 and ethyl ferulate (8) had the strongest inhibitory effects, with IC50 values of 3.03 ± 0.73 and 3.56 ± 0.43 µM, respectively. Compounds 2, 4, and 7 had moderate activity.

Keywords: Eurycoma longifolia, Simaroubaceae, eurylongilactone A, quassinoid, NO production, anti-inflammation.

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Article Details

Year: 2020
Page: [455 - 458]
Pages: 4
DOI: 10.2174/1570178617666191218104241
Price: $65

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