Background: Several studies showed a close link between metabolic syndrome (MetS), type
2 diabetes (T2DM) and cerebrovascular diseases. There is considerable debate regarding the role of uric
acid (UA) as a risk factor in these conditions.
Objective: The aim of this narrative review is to discuss the links between UA, MetS, T2DM and cerebrovascular
Methods: An extensive review has been conducted based on the scientific literature published in English,
and indexed in MEDLINE (through PubMed), EMBASE, the Cochrane Library, the Agency for
Healthcare Research and Quality, and Google Scholar from January to May 2019. Additional relevant
studies published after the initial review were also considered during the period of June 2019-October
2019, during which, this manuscript was written. The Mesh Terms considered were: uric acid, antioxidant,
oxidant, metabolic syndrome, diabetes, cerebrovascular diseases, stroke, haemorrhagic stroke,
neurocognitive disorders, and their combinations.
Results: The literature review shows a dose-dependent inflammatory action of UA, which occurs with
serum concentrations >4 mg/dl (>0.24 mmol/l), representing one of the contributors to the chronic inflammatory
process that underlies metabolic and cerebrovascular diseases.
Conclusion: UA, which is associated with arterial hypertension and cardiovascular diseases, represents
one of the indicators of oxidative homeostasis. Increasing concentrations represent a status of active
inflammation which is observed with metabolic and cerebrovascular diseases.