Aim: We aimed to review the drug delivery approaches including a novel drug delivery
system of doxorubicin as an important anticancer drug.
Background: Doxorubicin (DOX) is widely used against breast, uterine, ovarian, lung and cervical
cancer. It is listed among the essential medicines by WHO and is thus a very important drug
that can be used to fight against cancer. Despite its effectiveness, the use of the drug is limited due
to its dose-dependent toxicity. Several studies based on the DOX have suggested the need for
novel drug delivery formulations in the treatment of malignant and cancerous diseases due to its
Objective: This review focuses on the different formulations of DOX which is a useful drug in the
management of cancers, but associated with toxicity thus these approaches found applicability in
the reduction of its toxicity.
Methods: We searched the scientific database using cancer, DOX, and different formulations as
the keywords. Here in only peer-reviewed research articles collected which were useful to our
Results: This study is based on an examination of the recent advancements of its novel drug delivery
formulations. DOX hydrochloride is the first liposomal anticancer drug, administered via
the intravenous route, and also clinically approved for the treatment of lymphomas, leukemias,
and solid tumors. DOX is prepared into a liposomal formulation that contains polyethylene glycol
(PEG) layer around DOX containing liposome made by pegylation process. DOX also formulated
in nano-formulations which is also discussed herein led to reduced toxicity and increased efficacy.
Conclusion: In the review, we described the significance of DOX in the form of different delivery
approaches in the management of cancers with a reduction in the associated toxicity.